4-(4,5-dimethoxy-2-iodophenyl)-5-(2,4-dimethoxy-6-hydroxyphenyl)-1-phenylpyrazole

Base Information

Chemical Name:4-(4,5-dimethoxy-2-iodophenyl)-5-(2,4-dimethoxy-6-hydroxyphenyl)-1-phenylpyrazole
CAS No.:290353-20-7
Molecular Formula:C₂₅H₂₃IN₂O₅
Molecular Weight:558.373
Hs Code.:

Synonyms:4-(4,5-dimethoxy-2-iodophenyl)-5-(2,4-dimethoxy-6-hydroxyphenyl)-1-phenylpyrazole

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Chemical Property of 4-(4,5-dimethoxy-2-iodophenyl)-5-(2,4-dimethoxy-6-hydroxyphenyl)-1-phenylpyrazole

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Technology Process of 4-(4,5-dimethoxy-2-iodophenyl)-5-(2,4-dimethoxy-6-hydroxyphenyl)-1-phenylpyrazole

There total 9 articles about 4-(4,5-dimethoxy-2-iodophenyl)-5-(2,4-dimethoxy-6-hydroxyphenyl)-1-phenylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 478316-45-9
3,5-dimethoxy-2-[4-(4,5-dimethoxy-2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl benzoate

: 290353-20-7
4-(4,5-dimethoxy-2-iodophenyl)-5-(2,4-dimethoxy-6-hydroxyphenyl)-1-phenylpyrazole

Guidance literature:: With potassium hydroxide; In methanol; water; at 70 ℃; for 2h;
DOI:10.1016/S0040-4039(00)00621-3

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 290353-20-7
4-(4,5-dimethoxy-2-iodophenyl)-5-(2,4-dimethoxy-6-hydroxyphenyl)-1-phenylpyrazole

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / iodine monochloride / acetic acid / 1.5 h / 20 °C

2: SOCl₂ / toluene / 3.5 h / 135 °C

3: 65 percent / BF₃*OEt₂ / toluene / 7 h / 140 °C

4: 95 percent / NaOH; triethylbenzylammonium chloride / tetrahydrofuran / 4 h / 20 °C

5: 58 percent / toluene / 90 °C

6: Na₂CO₃; HOAc / methanol; H₂O / 145 °C / pH 4

With sodium hydroxide; thionyl chloride; boron trifluoride diethyl etherate; N-benzyl-N,N,N-triethylammonium chloride; Iodine monochloride; sodium carbonate; acetic acid; In tetrahydrofuran; methanol; water; acetic acid; toluene; 3: Friedel-Crafts acylation / 5: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j

Reference yield:

: 35323-09-2
(2-iodo-4,5-dimethoxyphenyl)acetic acid

: 290353-20-7
4-(4,5-dimethoxy-2-iodophenyl)-5-(2,4-dimethoxy-6-hydroxyphenyl)-1-phenylpyrazole

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / toluene / 3.5 h / 135 °C

2: 65 percent / BF₃*OEt₂ / toluene / 7 h / 140 °C

3: 95 percent / NaOH; triethylbenzylammonium chloride / tetrahydrofuran / 4 h / 20 °C

4: 58 percent / toluene / 90 °C

5: Na₂CO₃; HOAc / methanol; H₂O / 145 °C / pH 4

With sodium hydroxide; thionyl chloride; boron trifluoride diethyl etherate; N-benzyl-N,N,N-triethylammonium chloride; sodium carbonate; acetic acid; In tetrahydrofuran; methanol; water; toluene; 2: Friedel-Crafts acylation / 4: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j