3,5-dimethoxy-2-[4-(4,5-dimethoxy-2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl benzoate

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Chemical Name:3,5-dimethoxy-2-[4-(4,5-dimethoxy-2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl benzoate
CAS No.:478316-45-9
Molecular Formula:C₃₂H₂₇IN₂O₆
Molecular Weight:662.481
Hs Code.:

Synonyms:3,5-dimethoxy-2-[4-(4,5-dimethoxy-2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl benzoate

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Chemical Property of 3,5-dimethoxy-2-[4-(4,5-dimethoxy-2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl benzoate

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Technology Process of 3,5-dimethoxy-2-[4-(4,5-dimethoxy-2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl benzoate

There total 6 articles about 3,5-dimethoxy-2-[4-(4,5-dimethoxy-2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 100-63-0
phenylhydrazine

: Benzoic acid 2-[(E)-3-dimethylamino-2-(2-iodo-4,5-dimethoxy-phenyl)-acryloyl]-3,5-dimethoxy-phenyl ester

: 478316-45-9
3,5-dimethoxy-2-[4-(4,5-dimethoxy-2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl benzoate

Guidance literature:: With sodium carbonate; acetic acid; In methanol; water; at 140 ℃; pH=4;
DOI:10.1016/S0040-4039(00)00621-3

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 478316-45-9
3,5-dimethoxy-2-[4-(4,5-dimethoxy-2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / iodine monochloride / acetic acid / 1.5 h / 20 °C

2: SOCl₂ / toluene / 3.5 h / 135 °C

3: 65 percent / BF₃*OEt₂ / toluene / 7 h / 140 °C

4: 95 percent / NaOH; triethylbenzylammonium chloride / tetrahydrofuran / 4 h / 20 °C

5: 58 percent / toluene / 90 °C

6: 58 percent / Na₂CO₃; HOAc / methanol; H₂O / 145 °C / pH 4

With sodium hydroxide; thionyl chloride; boron trifluoride diethyl etherate; N-benzyl-N,N,N-triethylammonium chloride; Iodine monochloride; sodium carbonate; acetic acid; In tetrahydrofuran; methanol; water; acetic acid; toluene; 3: Friedel-Crafts acylation / 5: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j

Reference yield:

: 35323-09-2
(2-iodo-4,5-dimethoxyphenyl)acetic acid

: 478316-45-9
3,5-dimethoxy-2-[4-(4,5-dimethoxy-2-iodophenyl)-2-phenyl-2H-pyrazol-3-yl]phenyl benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / toluene / 3.5 h / 135 °C

2: 65 percent / BF₃*OEt₂ / toluene / 7 h / 140 °C

3: 95 percent / NaOH; triethylbenzylammonium chloride / tetrahydrofuran / 4 h / 20 °C

4: 58 percent / toluene / 90 °C

5: 58 percent / Na₂CO₃; HOAc / methanol; H₂O / 145 °C / pH 4

With sodium hydroxide; thionyl chloride; boron trifluoride diethyl etherate; N-benzyl-N,N,N-triethylammonium chloride; sodium carbonate; acetic acid; In tetrahydrofuran; methanol; water; toluene; 2: Friedel-Crafts acylation / 4: Vilsmeier-Haack reaction;
DOI:10.1021/jo025767j