(R)-methyl 4-(3-isopropyl-2-oxo-4-(4-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)-2-(methylsulfonyl)-5-nitrobenzoate

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Chemical Name:(R)-methyl 4-(3-isopropyl-2-oxo-4-(4-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)-2-(methylsulfonyl)-5-nitrobenzoate
CAS No.:1456704-62-3
Molecular Formula:C₂₁H₂₂F₃N₅O₇S
Molecular Weight:545.496
Hs Code.:

Synonyms:(R)-methyl 4-(3-isopropyl-2-oxo-4-(4-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)-2-(methylsulfonyl)-5-nitrobenzoate

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Chemical Property of (R)-methyl 4-(3-isopropyl-2-oxo-4-(4-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)-2-(methylsulfonyl)-5-nitrobenzoate

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Technology Process of (R)-methyl 4-(3-isopropyl-2-oxo-4-(4-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)-2-(methylsulfonyl)-5-nitrobenzoate

There total 4 articles about (R)-methyl 4-(3-isopropyl-2-oxo-4-(4-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)-2-(methylsulfonyl)-5-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1456704-61-2
(R)-methyl-2-fluoro-4-(3-isopropyl-2-oxo-4-(4-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)-5-nitrobenzoate

: 1456704-62-3
(R)-methyl 4-(3-isopropyl-2-oxo-4-(4-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)-2-(methylsulfonyl)-5-nitrobenzoate

Guidance literature:: With sodium methansulfinate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 33034-67-2
2-chloro-4-trifluoromethylpyrimidine

: 1456704-62-3
(R)-methyl 4-(3-isopropyl-2-oxo-4-(4-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)-2-(methylsulfonyl)-5-nitrobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

2.1: potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 0 °C

2.2: 2.08 h / -78 - -50 °C

3.1: sodium methansulfinate / N,N-dimethyl-formamide / 3 h / 20 °C

With potassium tert-butylate; sodium methansulfinate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1456693-03-0
(R)-3-isopropylpiperazin-2-one hydrochloride

: 1456704-62-3
(R)-methyl 4-(3-isopropyl-2-oxo-4-(4-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)-2-(methylsulfonyl)-5-nitrobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

2.1: potassium tert-butylate / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 0 °C

2.2: 2.08 h / -78 - -50 °C

3.1: sodium methansulfinate / N,N-dimethyl-formamide / 3 h / 20 °C

With potassium tert-butylate; sodium methansulfinate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;