33034-67-2

Basic information

• Product Name: 2-Chloro-4-(trifluoromethyl)pyrimidine
• Synonyms: BUTTPARK 27\08-69;4-(TRIFLUOROMETHYL)-2-CHLOROPYRIMIDINE;2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE;2-Chloro-4-(trifluoromethyl)pyrimidine 99%;2-Chloro-4-(trifluoromethyl)pyrimidine99%;Pyrimidine, 2-chloro-4-(trifluoromethyl)-
• CAS NO: 33034-67-2
• Molecular Formula: C₅H₂ClF₃N₂
• Molecular Weight: 182.53
• EINECS: 1312995-182-4
• Product Categories: Halides;Pyrazines, Pyrimidines & Pyridazines;Pyrimidine;Pyrimidine series;Nucleotides and Nucleosides;Pyrimidines;Bases & Related Reagents;Nucleotides;Pyrazines, Pyrimidines & Pyridazines;Boronic Acid;Heterocyclic Compounds;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PyrimidinesHeterocyclic Building Blocks;Variety of halogenated heterocyclic series;Fluorine series
• Mol File: 33034-67-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 60 °C10 mm Hg(lit.)
• Flash Point: 120 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 1.513 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.154mmHg at 25°C
• Refractive Index: n20/D 1.447(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -3.98±0.20(Predicted)
• CAS DataBase Reference: 2-Chloro-4-(trifluoromethyl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-(trifluoromethyl)pyrimidine(33034-67-2)
• EPA Substance Registry System: 2-Chloro-4-(trifluoromethyl)pyrimidine(33034-67-2)

Safety Data

• Hazard Codes: Xi,F
• Statements: 10-36/37/38
• Safety Statements: 16-26-36-37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 33034-67-2(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Liquid

Uses

2-Chloro-4-(trifluoromethyl)pyrimidine may be used to investigate the effect of chemical substitutions on the interfacial interactions of pyrimidines with the phospholipid-mimic immobilized-artificial-membrane (IAM) chromatographic stationary phase. Monocyclic pyrimidine nucleic acid bases (nucleobases) were reported to behave differently from their bicyclic purine analogs.

General Description

2-Chloro-4-(trifluoromethyl)pyrimidine is a pyrimidine derivative. Its density and refractive index have been determined.

InChI:InChI=1/C5H2ClF3N2/c6-4-10-2-1-3(11-4)5(7,8)9/h1-2H

Downstream Products

• 676559-94-7 (4-methyl-1-(4-trifluoromethyl-pyrimidin-2-yl)-piperidin-4-yl)-carbamic acid benzyl ester 
• 1095009-60-1 C₃₂H₃₁F₃N₄O₄ 
• 1272665-68-5 C₁₂H₈F₃N₃O 
• 1312536-72-3 N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine 
• 1312536-89-2 N-{3-[2-(1-{[tert-butyl-(dimethyl)silyl]oxy}cyclobutyl)-1,3-thiazol-5-yl]-5-nitrophenyl}-4-(trifluoromethyl)pyrimidin-2-amine 
• 1312536-90-5 5-[2-(1-{[tert-butyl(dimethyl)silyl]oxy}cyclobutyl)-1,3-thiazol-5-yl]-N-[4-(trifluoromethyl)pyrimidin-2-yl]benzene-1,3-diamine 
• 1312497-47-4 N-(3-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)acetamide 
• 1312536-91-6 tert-butyl {3-[2-(1-{[tert-butyl(dimethyl)silyl]oxy}cyclobutyl)-1,3-thiazol-5-yl]-5-nitrophenyl}[4-(trifluoromethyl)pyrimidin-2-yl]carbamate 
• 1312536-92-7 tert-butyl {3-amino-5-[2-(1-{[tert-butyl(dimethyl)silyl]oxy}cyclobutyl)-1,3-thiazol-5-yl]phenyl}[4-(trifluoromethyl)pyrimidin-2-yl]carbamate 
• 1312536-93-8 tert-butyl {3-[2-(1-{[tert-butyl(dimethyl)silyl]oxy}cyclobutyl)-1,3-thiazol-5-yl]-5[(cyclopentylcarbamoyl)amino]phenyl}[4-(trifluoromethyl)pyrimidin-2-yl]carbamate 
• 1312498-13-7 1-cyclopentyl-3-(3-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)urea 
• 1312479-85-8 1-[5-(2-fluoro-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]cyclobutan-1-ol 
• 1312479-93-8 1-{5-[3-chloro-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]-1,3-thiazol-2-yl}cycIobutan-1-ol 
• 1312496-52-8 tert-butyl 4-{1-hydroxy-1-[5-(3-{[4-(trifluoromethyl)-pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]ethyl}piperidine-1-carboxylate