4-(2-fluoro-4-(3-(5-nitrofuran-2-yl)-4,5-dihydroisoxazol-5-yl)phenyl)morpholine

Base Information

Chemical Name:4-(2-fluoro-4-(3-(5-nitrofuran-2-yl)-4,5-dihydroisoxazol-5-yl)phenyl)morpholine
CAS No.:1401100-44-4
Molecular Formula:C₁₇H₁₆FN₃O₅
Molecular Weight:361.33
Hs Code.:

Synonyms:4-(2-fluoro-4-(3-(5-nitrofuran-2-yl)-4,5-dihydroisoxazol-5-yl)phenyl)morpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-fluoro-4-(3-(5-nitrofuran-2-yl)-4,5-dihydroisoxazol-5-yl)phenyl)morpholine

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Technology Process of 4-(2-fluoro-4-(3-(5-nitrofuran-2-yl)-4,5-dihydroisoxazol-5-yl)phenyl)morpholine

There total 3 articles about 4-(2-fluoro-4-(3-(5-nitrofuran-2-yl)-4,5-dihydroisoxazol-5-yl)phenyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.3%

: 1401100-54-6
4-(2-fluoro-4-vinylphenyl)morpholine

: 22296-92-0
N-hydroxy-5-nitrofuran-2-carbimidoyl chloride

: 1401100-44-4
4-(2-fluoro-4-(3-(5-nitrofuran-2-yl)-4,5-dihydroisoxazol-5-yl)phenyl)morpholine

Guidance literature:: With triethylamine; In chloroform; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2012.08.023

Reference yield:

: 916814-07-8
1-bromo-4-ethenyl-2-fluorobenzene

: 1401100-44-4
4-(2-fluoro-4-(3-(5-nitrofuran-2-yl)-4,5-dihydroisoxazol-5-yl)phenyl)morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; sodium butanolate; johnphos / toluene / 12 h / 80 °C

2: triethylamine / chloroform / 2 h / 20 °C

With palladium diacetate; triethylamine; sodium butanolate; johnphos; In chloroform; toluene;
DOI:10.1016/j.bmc.2012.08.023

Reference yield:

: 136434-77-0
4-bromo-3-fluoroiodobenzene

: 1401100-44-4
4-(2-fluoro-4-(3-(5-nitrofuran-2-yl)-4,5-dihydroisoxazol-5-yl)phenyl)morpholine

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.08 h / 160 °C / Microwave irradiation

2: palladium diacetate; sodium butanolate; johnphos / toluene / 12 h / 80 °C

3: triethylamine / chloroform / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; triethylamine; sodium butanolate; johnphos; In chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2012.08.023