Technology Process of ethyl 5-(4-trifluoromethylbenzyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate
There total 4 articles about ethyl 5-(4-trifluoromethylbenzyl)-4-(2,5,5-trimethyl-1,3-dioxan-2-yl)-1,2-oxazole-3-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium diacetate; potassium carbonate; johnphos;
In
N,N-dimethyl-formamide;
at 140 ℃;
for 0.341667h;
Inert atmosphere;
Microwave irradiation;
DOI:10.1016/j.tetlet.2011.08.096
- Guidance literature:
-
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid / benzene / 18 h / Reflux
2: N-Bromosuccinimide / tetrachloromethane / 24 h / Mercury lamp irradiation
3: palladium diacetate; potassium carbonate; johnphos / N,N-dimethyl-formamide / 0.34 h / 140 °C / Inert atmosphere; Microwave irradiation
With
N-Bromosuccinimide; palladium diacetate; potassium carbonate; toluene-4-sulfonic acid; johnphos;
In
tetrachloromethane; N,N-dimethyl-formamide; benzene;
3: Suzuki-Miyaura cross-coupling;
DOI:10.1016/j.tetlet.2011.08.096
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-Bromosuccinimide / tetrachloromethane / 24 h / Mercury lamp irradiation
2: palladium diacetate; potassium carbonate; johnphos / N,N-dimethyl-formamide / 0.34 h / 140 °C / Inert atmosphere; Microwave irradiation
With
N-Bromosuccinimide; palladium diacetate; potassium carbonate; johnphos;
In
tetrachloromethane; N,N-dimethyl-formamide;
2: Suzuki-Miyaura cross-coupling;
DOI:10.1016/j.tetlet.2011.08.096
