(R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid

Base Information

Chemical Name:(R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid
CAS No.:1258740-29-2
Molecular Formula:C₁₈H₂₀FNO₅S
Molecular Weight:381.425
Hs Code.:

Synonyms:(R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid

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Technology Process of (R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid

There total 1 articles about (R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1258740-15-6
tert-butyl (R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate

: 1258740-29-2
(R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.tet.2010.09.025

Reference yield: 41.0%

: 1258740-29-2
(R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid

: 1258740-40-7
7-fluoro-6-methoxynaphthalen-1-ol

: 1258740-39-4
(R)-N-(6-fluoro-7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: (R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid; With phosphorus pentachloride; In dichloromethane; at 0 ℃; Inert atmosphere;

With tin(IV) chloride; In dichloromethane; at 0 ℃; regiospecific reaction; Inert atmosphere;
DOI:10.1016/j.tet.2010.09.025