tert-butyl (R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate

Base Information

Chemical Name:tert-butyl (R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate
CAS No.:1258740-15-6
Molecular Formula:C₂₂H₂₈FNO₅S
Molecular Weight:437.532
Hs Code.:

Synonyms:tert-butyl (R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate

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Chemical Property of tert-butyl (R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate

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Technology Process of tert-butyl (R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate

There total 1 articles about tert-butyl (R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: (4-fluoro-3-methoxyphenyl)magnesium bromide

: 1258740-08-7
tert-butyl (S)-2-(1-tosylaziridin-2-yl)acetate

: 1258740-21-4
(E)-4-(toluenesulfonylamino)-but-2-enoic acid tert-butyl ester

: 1258740-15-6
tert-butyl (R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate

Guidance literature:: (4-fluoro-3-methoxyphenyl)magnesium bromide; tert-butyl (S)-2-(1-tosylaziridin-2-yl)acetate; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at -40 - 0 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at 0 ℃; regioselective reaction;
DOI:10.1016/j.tet.2010.09.025

Reference yield: 84.0%

: 1258740-15-6
tert-butyl (R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate

: 1258740-29-2
(R)-4-(4-fluoro-3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.tet.2010.09.025