(2E,6E)-9-((1R)-2,2-dimethyl-6-methylenecyclohexyl)-3,7-dimethyl-1-(tetrahydro-2-pyranyl)oxy-2,6-nonadiene

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Chemical Name:(2E,6E)-9-((1R)-2,2-dimethyl-6-methylenecyclohexyl)-3,7-dimethyl-1-(tetrahydro-2-pyranyl)oxy-2,6-nonadiene
CAS No.:502763-44-2
Molecular Formula:C₂₅H₄₂O₂
Molecular Weight:374.607
Hs Code.:

Synonyms:(2E,6E)-9-((1R)-2,2-dimethyl-6-methylenecyclohexyl)-3,7-dimethyl-1-(tetrahydro-2-pyranyl)oxy-2,6-nonadiene

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Chemical Property of (2E,6E)-9-((1R)-2,2-dimethyl-6-methylenecyclohexyl)-3,7-dimethyl-1-(tetrahydro-2-pyranyl)oxy-2,6-nonadiene

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Technology Process of (2E,6E)-9-((1R)-2,2-dimethyl-6-methylenecyclohexyl)-3,7-dimethyl-1-(tetrahydro-2-pyranyl)oxy-2,6-nonadiene

There total 4 articles about (2E,6E)-9-((1R)-2,2-dimethyl-6-methylenecyclohexyl)-3,7-dimethyl-1-(tetrahydro-2-pyranyl)oxy-2,6-nonadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 502763-42-0
(R)-(-)-1-[1'-(benzenesulfonyl)methyl]-2,2-dimethyl-6-methylenecyclohexane

: 502763-31-7
(2E,6E)-2,6-dimethyl-8-(tetrahydro-2H-pyran-2-yloxy)octa-2,6-dienyl-4-methylbenzenesulfonate

: 502763-44-2
(2E,6E)-9-((1R)-2,2-dimethyl-6-methylenecyclohexyl)-3,7-dimethyl-1-(tetrahydro-2-pyranyl)oxy-2,6-nonadiene

Guidance literature:: (R)-(-)-1-[1'-(benzenesulfonyl)methyl]-2,2-dimethyl-6-methylenecyclohexane; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 1h;

(2E,6E)-2,6-dimethyl-8-(tetrahydro-2H-pyran-2-yloxy)octa-2,6-dienyl-4-methylbenzenesulfonate; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

With disodium hydrogenphosphate; ethanol; sodium; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/S0040-4020(02)01455-2

Reference yield:

: 66408-80-8,70238-39-0,80444-67-3,143590-48-1,38290-53-8
(2E,6E)-2,6-dimethyl-8-((tetrahydro-2H-pyran-2-yl)oxy)octa-2,6-dien-1-ol

: 502763-44-2
(2E,6E)-9-((1R)-2,2-dimethyl-6-methylenecyclohexyl)-3,7-dimethyl-1-(tetrahydro-2-pyranyl)oxy-2,6-nonadiene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / (C₂H₅)3N; trimethylammonium hydrochloride / toluene / 2 h

2.1: n-C₄H₉Li / tetrahydrofuran / 1 h / 0 °C

2.2: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidone / tetrahydrofuran / 16 h / 0 - 20 °C

2.3: 41 percent / Na₂HPO₄; Na; C₂H₅OH / tetrahydrofuran / 16 h / 20 °C

With n-butyllithium; trimethylamine hydrochloride; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(02)01455-2

Reference yield:

: 166022-33-9
((R)-(-)-2,2-dimethyl-6-methylene-1-cyclohexyl)methanol

: 502763-44-2
(2E,6E)-9-((1R)-2,2-dimethyl-6-methylenecyclohexyl)-3,7-dimethyl-1-(tetrahydro-2-pyranyl)oxy-2,6-nonadiene

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / tributylphosphine; pyridine / 15 h / 20 °C

2.1: 86 percent / Oxone (R) / methanol; H₂O / 3 h / 20 °C

3.1: n-C₄H₉Li / tetrahydrofuran / 1 h / 0 °C

3.2: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidone / tetrahydrofuran / 16 h / 0 - 20 °C

3.3: 41 percent / Na₂HPO₄; Na; C₂H₅OH / tetrahydrofuran / 16 h / 20 °C

With pyridine; Oxone; n-butyllithium; tributylphosphine; In tetrahydrofuran; methanol; water;
DOI:10.1016/S0040-4020(02)01455-2