(2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide hydrochloric acid salt

Base Information

Chemical Name:(2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide hydrochloric acid salt
CAS No.:1310450-65-7
Molecular Formula:C₂₃H₂₉N₃O₄*ClH
Molecular Weight:447.962
Hs Code.:

Synonyms:(2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide hydrochloric acid salt

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Chemical Property of (2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide hydrochloric acid salt

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Technology Process of (2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide hydrochloric acid salt

There total 8 articles about (2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide hydrochloric acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1173158-84-3
(2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide

: 1310450-65-7
(2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide hydrochloric acid salt

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 22 ℃;

Reference yield:

: 100564-78-1,108524-68-1,142926-43-0,82732-07-8
(2R)-(tert-butoxycarbonylamino)-4-phenylbutanoic acid

: 1310450-65-7
(2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide hydrochloric acid salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 22 °C

1.2: 0.5 h

2.1: hydrogenchloride; triethylsilane / 1,4-dioxane / 12.5 h / 22 °C

3.1: sodium cyanoborohydride / methanol / 1 h / 0 °C

3.2: 4 h

4.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 22 °C

With hydrogenchloride; triethylsilane; sodium cyanoborohydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

: 6232-11-7
methyl 4-(aminomethyl)benzoate hydrochloride

: 1310450-65-7
(2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide hydrochloric acid salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.25 h

3.1: Dess-Martin periodane / dichloromethane / 0.08 h / 22 °C / Reflux

4.1: sodium cyanoborohydride / methanol / 1 h / 0 °C

4.2: 4 h

5.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 22 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium cyanoborohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane;