(2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide

Base Information

Chemical Name:(2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide
CAS No.:1173158-84-3
Molecular Formula:C₂₃H₂₉N₃O₄
Molecular Weight:411.501
Hs Code.:

Synonyms:(2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide

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Chemical Property of (2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide

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Technology Process of (2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide

There total 6 articles about (2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1173158-82-1
(2R)-2-amino-N-methoxy-4-phenylbutanamide

: 1007859-13-3
N-[(4-formylphenyl)methyl]prop-2-enyloxycarboxamide

: 1173158-84-3
(2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide

Guidance literature:: (2R)-2-amino-N-methoxy-4-phenylbutanamide; N-[(4-formylphenyl)methyl]prop-2-enyloxycarboxamide; With sodium cyanoborohydride; In methanol; at 0 ℃; for 1h;

With acetic acid; In methanol; for 4h;

Reference yield:

: 100564-78-1,108524-68-1,142926-43-0,82732-07-8
(2R)-(tert-butoxycarbonylamino)-4-phenylbutanoic acid

: 1173158-84-3
(2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 22 °C

1.2: 0.5 h

2.1: hydrogenchloride; triethylsilane / 1,4-dioxane / 12.5 h / 22 °C

3.1: sodium cyanoborohydride / methanol / 1 h / 0 °C

3.2: 4 h

With hydrogenchloride; triethylsilane; sodium cyanoborohydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 6232-11-7
methyl 4-(aminomethyl)benzoate hydrochloride

: 1173158-84-3
(2R)-N-methoxy-4-phenyl-2-[({4-[(prop-2-enyloxycarbonylamino)methyl]phenyl}methyl)amino]butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.25 h

3.1: Dess-Martin periodane / dichloromethane / 0.08 h / 22 °C / Reflux

4.1: sodium cyanoborohydride / methanol / 1 h / 0 °C

4.2: 4 h

With lithium aluminium tetrahydride; sodium cyanoborohydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;