2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanamide

Base Information

Chemical Name:2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanamide
CAS No.:1606974-88-2
Molecular Formula:C₂₃H₂₄ClN₃O
Molecular Weight:393.916
Hs Code.:

Synonyms:2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanamide

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Chemical Property of 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanamide

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Technology Process of 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanamide

There total 5 articles about 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1606977-29-0
2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanoic acid

: 1606974-88-2
2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanamide

Guidance literature:: 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; at 0 ℃; for 6h;

With ammonia; In methanol; dichloromethane; at 0 ℃; for 15h;

Reference yield:

: 68682-48-4
methyl 2-methyl-2-(4-methylphenyl)propanoate

: 1606974-88-2
2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3.5 h / Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 20 h / 80 °C / Inert atmosphere

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 2 h / 90 °C / Sealed tube; Inert atmosphere

4.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 7 h / 50 °C

4.2: pH Ca_. 5

5.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,4-dioxane; dichloromethane / 6 h / 0 °C

5.2: 15 h / 0 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; lithium hydroxide monohydrate; 2,2'-azobis(isobutyronitrile); water; sodium carbonate; potassium carbonate; N,N-dimethyl-formamide; In 1,4-dioxane; tetrachloromethane; dichloromethane; water;

Reference yield:

: 1606977-28-9
methyl 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanoate

: 1606974-88-2
2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 7 h / 50 °C

1.2: pH Ca_. 5

2.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,4-dioxane; dichloromethane / 6 h / 0 °C

2.2: 15 h / 0 °C

With oxalyl dichloride; lithium hydroxide monohydrate; water; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane;