2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanoic acid

Base Information

Chemical Name:2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanoic acid
CAS No.:1606977-29-0
Molecular Formula:C₂₃H₂₃ClN₂O₂
Molecular Weight:394.901
Hs Code.:

Synonyms:2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanoic acid

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Chemical Property of 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanoic acid

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Technology Process of 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanoic acid

There total 3 articles about 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68682-48-4
methyl 2-methyl-2-(4-methylphenyl)propanoate

: 1606977-29-0
2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3.5 h / Reflux

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 20 h / 80 °C / Inert atmosphere

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 2 h / 90 °C / Sealed tube; Inert atmosphere

4.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 7 h / 50 °C

4.2: pH Ca_. 5

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; 2,2'-azobis(isobutyronitrile); water; sodium carbonate; potassium carbonate; In 1,4-dioxane; tetrachloromethane; water;

Reference yield:

: 147247-29-8
methyl 2-(4-(bromomethyl)phenyl)-2-methylpropanoate

: 1606977-29-0
2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 20 h / 80 °C / Inert atmosphere

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 2 h / 90 °C / Sealed tube; Inert atmosphere

3.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 7 h / 50 °C

3.2: pH Ca_. 5

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; sodium carbonate; potassium carbonate; In 1,4-dioxane; water;

Reference yield:

: ethyl 2-methyl-2-(4-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)phenyl)propanoate

: 1606977-29-0
2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)methyl)phenyl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 2 h / 90 °C / Sealed tube; Inert atmosphere

2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 7 h / 50 °C

2.2: pH Ca_. 5

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; water; sodium carbonate; In 1,4-dioxane; water;