Methyl (2R,4S)-2-Chloro-2-oxo-3-benzyl-1,3,2-oxazaphospholidine-4-carboxylate

Base Information

Chemical Name:Methyl (2R,4S)-2-Chloro-2-oxo-3-benzyl-1,3,2-oxazaphospholidine-4-carboxylate
CAS No.:123672-99-1
Molecular Formula:C₁₁H₁₃ClNO₄P
Molecular Weight:289.655
Hs Code.:

Synonyms:Methyl (2R,4S)-2-Chloro-2-oxo-3-benzyl-1,3,2-oxazaphospholidine-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl (2R,4S)-2-Chloro-2-oxo-3-benzyl-1,3,2-oxazaphospholidine-4-carboxylate

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Technology Process of Methyl (2R,4S)-2-Chloro-2-oxo-3-benzyl-1,3,2-oxazaphospholidine-4-carboxylate

There total 5 articles about Methyl (2R,4S)-2-Chloro-2-oxo-3-benzyl-1,3,2-oxazaphospholidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.7%

: 123639-56-5
(S)-N-benzylserine methyl ester

: 123621-73-8,123672-99-1
(S)-3-Benzyl-2-chloro-2-oxo-2λ⁵-[1,3,2]oxazaphospholidine-4-carboxylic acid methyl ester

Guidance literature:: With triethylamine; trichlorophosphate; In toluene; at 20 ℃; for 2h;
DOI:10.1080/00397910008087103

Reference yield:

: 123639-56-5
(S)-N-benzylserine methyl ester

: 123672-99-1
Methyl (2R,4S)-2-Chloro-2-oxo-3-benzyl-1,3,2-oxazaphospholidine-4-carboxylate

Guidance literature:: With triethylamine; trichlorophosphate; In toluene; at 0 ℃; Yield given;
DOI:10.1021/jo00288a023

Reference yield:

: 100-52-7
benzaldehyde

: 123672-99-1
Methyl (2R,4S)-2-Chloro-2-oxo-3-benzyl-1,3,2-oxazaphospholidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) Et₃N 3) NaBH₄ / 1) MeOH

2: POCl₃, Et₃N / toluene / 0 °C

With sodium tetrahydroborate; triethylamine; trichlorophosphate; In toluene;
DOI:10.1021/jo00288a023