Technology Process of benzyl tert-butyl(6-nitropyridin-3-yl)propanedioate
There total 1 articles about benzyl tert-butyl(6-nitropyridin-3-yl)propanedioate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 20 ℃;
Inert atmosphere;
Schlenk technique;
Reflux;
DOI:10.1016/j.bmcl.2014.03.054
- Guidance literature:
-
Multi-step reaction with 5 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 20 °C / Inert atmosphere; Schlenk technique
2: N-Bromosuccinimide / tetrahydrofuran / 1 h / 20 °C / Cooling with ice; Inert atmosphere; Schlenk technique
3: benzyltriethylammonium bromide; tert.-butylnitrite / ethylene dibromide / 16 h / 20 °C / Inert atmosphere; Schlenk technique
4: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere; Schlenk technique
5: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Schlenk technique
With
N-Bromosuccinimide; tert.-butylnitrite; palladium 10% on activated carbon; hydrogen; palladium diacetate; benzyltriethylammonium bromide; sodium hydride; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene;
In
tetrahydrofuran; 1,4-dioxane; ethanol; ethylene dibromide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2014.03.054
