(4'R,4''S,6'S,6''S)-4',4''-(2-methylene-1,3-propanediyl)bis<6-<(tert-butyldiphenylsilyloxy)methyl>-2,2-dimethyl-1,3-dioxane>

Base Information

Chemical Name:(4'R,4''S,6'S,6''S)-4',4''-(2-methylene-1,3-propanediyl)bis<6-<(tert-butyldiphenylsilyloxy)methyl>-2,2-dimethyl-1,3-dioxane>
CAS No.:159691-89-1
Molecular Formula:C₅₀H₆₈O₆Si₂
Molecular Weight:821.257
Hs Code.:

Synonyms:(4'R,4''S,6'S,6''S)-4',4''-(2-methylene-1,3-propanediyl)bis<6-<(tert-butyldiphenylsilyloxy)methyl>-2,2-dimethyl-1,3-dioxane>

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Chemical Property of (4'R,4''S,6'S,6''S)-4',4''-(2-methylene-1,3-propanediyl)bis<6-<(tert-butyldiphenylsilyloxy)methyl>-2,2-dimethyl-1,3-dioxane>

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Technology Process of (4'R,4''S,6'S,6''S)-4',4''-(2-methylene-1,3-propanediyl)bis<6-<(tert-butyldiphenylsilyloxy)methyl>-2,2-dimethyl-1,3-dioxane>

There total 8 articles about (4'R,4''S,6'S,6''S)-4',4''-(2-methylene-1,3-propanediyl)bis<6-<(tert-butyldiphenylsilyloxy)methyl>-2,2-dimethyl-1,3-dioxane> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 77-76-9
2,2-dimethoxy-propane

: 159691-88-0
(2S,4R,8S,10S)-1,11-bis(tert-butyldiphenylsilyloxy)-6-methylene-2,4,8,10-undecanetetraol

: 159691-89-1
(4'R,4''S,6'S,6''S)-4',4''-(2-methylene-1,3-propanediyl)bis<6-<(tert-butyldiphenylsilyloxy)methyl>-2,2-dimethyl-1,3-dioxane>

Guidance literature:: With camphor-10-sulfonic acid; In acetone; for 0.5h;

Reference yield:

: 102717-29-3
(5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)dihydrofuran-2(3H)-one

: 159691-89-1
(4'R,4''S,6'S,6''S)-4',4''-(2-methylene-1,3-propanediyl)bis<6-<(tert-butyldiphenylsilyloxy)methyl>-2,2-dimethyl-1,3-dioxane>

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 2.50m n-BuLi, diisopropylamine / 1.) hexane, THF, -78 deg C, 1 h; 2.) hexane, THF, -78 deg C, 1.5 h

3: 88 percent / camphorsulfonic acid / acetone / 0.5 h

With n-butyllithium; camphor-10-sulfonic acid; diisopropylamine; In acetone;

Reference yield:

: 159691-84-6
(3R,5S)-<(tert-butyldiphenylsilyloxy)methyl>-4,5-dihydro-3-<2-methylene-3-(tetrahydropyran-2-yloxy)propyl>-2(3H)-furanone

: 159691-89-1
(4'R,4''S,6'S,6''S)-4',4''-(2-methylene-1,3-propanediyl)bis<6-<(tert-butyldiphenylsilyloxy)methyl>-2,2-dimethyl-1,3-dioxane>

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / 1.95M bromine, PPh₃ / CH₂Cl₂ / 3 h / -20 °C

2: 1.) 1.50m n-BuLi, diisopropylamine / 1.) hexane, THF, -78 deg C, 1 h; 2.) hexane, THF, -78 deg C, 2.5 h then 10 min at room temp.

3: 21 percent / 2.20M n-BuLi, diisopropylamine, chlorotrimethylsilane / hexane; tetrahydrofuran / 1 h / -78 °C

5: 88 percent / camphorsulfonic acid / acetone / 0.5 h

With n-butyllithium; chloro-trimethyl-silane; camphor-10-sulfonic acid; bromine; diisopropylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; acetone;