1,4-bis(p-methoxybenzyl)-3-(2'-γ-butyrolactonyl)-2,5-piperazinedione (major diastereomer)

Base Information

Chemical Name:1,4-bis(p-methoxybenzyl)-3-(2'-γ-butyrolactonyl)-2,5-piperazinedione (major diastereomer)
CAS No.:95676-26-9
Molecular Formula:C₂₄H₂₆N₂O₆
Molecular Weight:438.48
Hs Code.:

Synonyms:1,4-bis(p-methoxybenzyl)-3-(2'-γ-butyrolactonyl)-2,5-piperazinedione (major diastereomer)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,4-bis(p-methoxybenzyl)-3-(2'-γ-butyrolactonyl)-2,5-piperazinedione (major diastereomer)

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Technology Process of 1,4-bis(p-methoxybenzyl)-3-(2'-γ-butyrolactonyl)-2,5-piperazinedione (major diastereomer)

There total 7 articles about 1,4-bis(p-methoxybenzyl)-3-(2'-γ-butyrolactonyl)-2,5-piperazinedione (major diastereomer) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 92216-26-7
1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(2-γ-butyrolactonyl)-2,5-piperazinedione (syn, minor diastereomer)

: 95676-26-9
1,4-bis(p-methoxybenzyl)-3-(2'-γ-butyrolactonyl)-2,5-piperazinedione (major diastereomer)

Guidance literature:: With hydrogen; nickel; In ethanol; for 2h; Heating;
DOI:10.1021/ja00297a034

Reference yield: 18.8%

: 51425-66-2
(4,5-dihydro-2-furanyloxy)(trimethyl)silane

: 95676-25-8
1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-2,5-piperazinedione

: 95676-26-9
1,4-bis(p-methoxybenzyl)-3-(2'-γ-butyrolactonyl)-2,5-piperazinedione (major diastereomer)

: 95676-27-0
1,4-bis(p-methoxybenzyl)-3-(2'-γ-butyrolactonyl)-2,5-piperazinedione (minor diastereomer)

Guidance literature:: With silver trifluoromethanesulfonate; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1021/ja00297a034

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 95676-26-9
1,4-bis(p-methoxybenzyl)-3-(2'-γ-butyrolactonyl)-2,5-piperazinedione (major diastereomer)

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / dimethylformamide / 25 °C

2: 66 percent / N-bromosuccinimide / benzoyl peroxide / CCl₄ / 1 h / Heating

3: 1.) NaH / 1.) THF, 30 min; 2.) THF, 25 deg C, 10 min

4: 30.5 percent / AgOTf / CH₂Cl₂ / 0.5 h / Ambient temperature

With N-Bromosuccinimide; silver trifluoromethanesulfonate; sodium hydride; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00297a034