{5-Methyl-2-[(4R,4'S,4''S)-4,4',4''-trimethyl-2''-((E)-styryl)-4,5,4',5',4'',5''-hexahydro-[2,4';2',4'']terthiazol-4-yl]-oxazol-4-yl}-methanol

Base Information

Chemical Name:{5-Methyl-2-[(4R,4'S,4''S)-4,4',4''-trimethyl-2''-((E)-styryl)-4,5,4',5',4'',5''-hexahydro-[2,4';2',4'']terthiazol-4-yl]-oxazol-4-yl}-methanol
CAS No.:257278-43-6
Molecular Formula:C₂₅H₂₈N₄O₂S₃
Molecular Weight:512.721
Hs Code.:

Synonyms:{5-Methyl-2-[(4R,4'S,4''S)-4,4',4''-trimethyl-2''-((E)-styryl)-4,5,4',5',4'',5''-hexahydro-[2,4';2',4'']terthiazol-4-yl]-oxazol-4-yl}-methanol

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Chemical Property of {5-Methyl-2-[(4R,4'S,4''S)-4,4',4''-trimethyl-2''-((E)-styryl)-4,5,4',5',4'',5''-hexahydro-[2,4';2',4'']terthiazol-4-yl]-oxazol-4-yl}-methanol

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Technology Process of {5-Methyl-2-[(4R,4'S,4''S)-4,4',4''-trimethyl-2''-((E)-styryl)-4,5,4',5',4'',5''-hexahydro-[2,4';2',4'']terthiazol-4-yl]-oxazol-4-yl}-methanol

There total 4 articles about {5-Methyl-2-[(4R,4'S,4''S)-4,4',4''-trimethyl-2''-((E)-styryl)-4,5,4',5',4'',5''-hexahydro-[2,4';2',4'']terthiazol-4-yl]-oxazol-4-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 157770-69-9
(4S)-4-methyl-4'<2'(4'S)-4'-methyl-4'(2''-(4''R)-4''-methyl-4''-(2'''-(4'''-methoxycarbonyl-5'''-methyl)oxazole)-Δ²-thiazoline)-Δ²-thiazoline>-2-cinnamyl-Δ²-thiazoline

: 257278-43-6
{5-Methyl-2-[(4R,4'S,4''S)-4,4',4''-trimethyl-2''-((E)-styryl)-4,5,4',5',4'',5''-hexahydro-[2,4';2',4'']terthiazol-4-yl]-oxazol-4-yl}-methanol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -30 ℃; for 1.5h;
DOI:10.1002/(SICI)1099-0690(199912)1999:12<3381::AID-EJOC3381>3.0.CO;2-W

Reference yield:

: 1100-88-5
benzyltriphenylphosphonium chloride

: 257278-43-6
{5-Methyl-2-[(4R,4'S,4''S)-4,4',4''-trimethyl-2''-((E)-styryl)-4,5,4',5',4'',5''-hexahydro-[2,4';2',4'']terthiazol-4-yl]-oxazol-4-yl}-methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 36 percent / 50 percent NaOH / H₂O; CH₂Cl₂ / 0.5 h / 20 °C

2.1: N₂O₄; NaOAc / CH₂Cl₂ / 0.75 h / -20 °C

2.2: 55 percent / CHCl₃ / 70 °C

3.1: 81 percent / DIBAH / tetrahydrofuran; hexane / 1.5 h / -30 °C

With sodium hydroxide; sodium acetate; dinitrogen tetraoxide; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; water; 1.1: Wittig reaction / 2.1: Nitrosation / 2.2: Rearrangement / 3.1: Reduction;
DOI:10.1002/(SICI)1099-0690(199912)1999:12<3381::AID-EJOC3381>3.0.CO;2-W

Reference yield:

: 138667-71-7,144370-38-7
(-)-Thiangazole

: 257278-43-6
{5-Methyl-2-[(4R,4'S,4''S)-4,4',4''-trimethyl-2''-((E)-styryl)-4,5,4',5',4'',5''-hexahydro-[2,4';2',4'']terthiazol-4-yl]-oxazol-4-yl}-methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: N₂O₄; NaOAc / CH₂Cl₂ / 0.75 h / -20 °C

1.2: 55 percent / CHCl₃ / 70 °C

2.1: 81 percent / DIBAH / tetrahydrofuran; hexane / 1.5 h / -30 °C

With sodium acetate; dinitrogen tetraoxide; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; 1.1: Nitrosation / 1.2: Rearrangement / 2.1: Reduction;
DOI:10.1002/(SICI)1099-0690(199912)1999:12<3381::AID-EJOC3381>3.0.CO;2-W