(E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoic acid

Base Information

• Chemical Name: (E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoic acid
• CAS No.: 1608496-50-9
• Molecular Formula: C₁₁H₈F₃N₃O₃
• Molecular Weight: 287.198
• Mol file: 1608496-50-9.mol

Synonyms:(E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoic acid

Chemical Property of (E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoic acid

There total 3 articles about (E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoate (1608496-49-6) → (E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoic acid (1608496-50-9)

Guidance literature:

methyl (E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoate; With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 20h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 0.166667h;

DOI:10.1002/ejoc.201301717

Reference yield:

methyl 2-(tert-butyldimethylsilyloxy)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}acrylate → (E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoic acid (1608496-50-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine tris(hydrogen fluoride) / methanol / 20 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride / methanol / 19 h / 20 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 h / 20 °C

3.2: 0.17 h / 20 °C

With lithium hydroxide monohydrate; hydroxylamine hydrochloride; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; methanol; water;

DOI:10.1002/ejoc.201301717

Reference yield:

C12H9F3N2O3 → (E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoic acid (1608496-50-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride / methanol / 19 h / 20 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 h / 20 °C

2.2: 0.17 h / 20 °C

With lithium hydroxide monohydrate; hydroxylamine hydrochloride; In tetrahydrofuran; methanol; water;

DOI:10.1002/ejoc.201301717

upstream raw materials:

methyl (E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoate

Downstream raw materials:

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