photopsammaplin

Base Information

• Chemical Name: photopsammaplin
• CAS No.: 1608496-42-9
• Molecular Formula: C₂₆H₂₄F₆N₈O₄S₂
• Molecular Weight: 690.65
• Mol file: 1608496-42-9.mol

Synonyms:photopsammaplin

Chemical Property of photopsammaplin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of photopsammaplin

There total 4 articles about photopsammaplin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

(E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoic acid (1608496-50-9) + cystamine dihydrochloride → photopsammaplin (1608496-42-9)

Guidance literature:

(E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoic acid; With 1-hydroxy-pyrrolidine-2,5-dione; In N,N-dimethyl-formamide; for 0.0833333h;

With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 3h;

cystamine dihydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1002/ejoc.201301717

Reference yield:

methyl 2-(tert-butyldimethylsilyloxy)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}acrylate → photopsammaplin (1608496-42-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine tris(hydrogen fluoride) / methanol / 20 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride / methanol / 19 h / 20 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 h / 20 °C

3.2: 0.17 h / 20 °C

4.1: 1-hydroxy-pyrrolidine-2,5-dione / N,N-dimethyl-formamide / 0.08 h

4.2: 3 h

4.3: 4 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; lithium hydroxide monohydrate; hydroxylamine hydrochloride; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201301717

Reference yield:

C12H9F3N2O3 → photopsammaplin (1608496-42-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride / methanol / 19 h / 20 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 h / 20 °C

2.2: 0.17 h / 20 °C

3.1: 1-hydroxy-pyrrolidine-2,5-dione / N,N-dimethyl-formamide / 0.08 h

3.2: 3 h

3.3: 4 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; lithium hydroxide monohydrate; hydroxylamine hydrochloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201301717

upstream raw materials:

methyl (E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoate

(E)-2-(hydroxyimino)-3-{3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}propanoic acid