[6-(4-{1-ethyl-1-[3-methyl-4-(4, 4, 4-trifluoro-3-hydroxy-3-trifluoromethyl-butyl)-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

Base Information

Chemical Name:[6-(4-{1-ethyl-1-[3-methyl-4-(4, 4, 4-trifluoro-3-hydroxy-3-trifluoromethyl-butyl)-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester
CAS No.:917025-82-2
Molecular Formula:C₃₃H₃₇F₆NO₃
Molecular Weight:609.652
Hs Code.:

[6-(4-{1-ethyl-1-[3-methyl-4-(4, 4, 4-trifluoro-3-hydroxy-3-trifluoromethyl-butyl)-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

Synonyms:[6-(4-{1-ethyl-1-[3-methyl-4-(4, 4, 4-trifluoro-3-hydroxy-3-trifluoromethyl-butyl)-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

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Chemical Property of [6-(4-{1-ethyl-1-[3-methyl-4-(4, 4, 4-trifluoro-3-hydroxy-3-trifluoromethyl-butyl)-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

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Technology Process of [6-(4-{1-ethyl-1-[3-methyl-4-(4, 4, 4-trifluoro-3-hydroxy-3-trifluoromethyl-butyl)-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

There total 10 articles about [6-(4-{1-ethyl-1-[3-methyl-4-(4, 4, 4-trifluoro-3-hydroxy-3-trifluoromethyl-butyl)-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 917022-90-3
4-(4-{1-ethyl-1-[3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-propyl}-2-methyl-phenyl)-1,1,1-trifluoro-2-trifluoromethyl-butan-2-ol

: 197376-47-9
ethyl (6-chloro-pyridin-3-yl)acetate

: 917025-82-2
[6-(4-{1-ethyl-1-[3-methyl-4-(4, 4, 4-trifluoro-3-hydroxy-3-trifluoromethyl-butyl)-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 140 ℃; for 0.116667h; Irradiation;

Reference yield:

: 865235-97-8
4-{1-ethyl-1-[3-methyl-4-(4,4,4-trifluoro-3-hydroxy-3-trifluoromethyl-1-butynyl)phenyl]propyl}-2-methylphenol

: 917025-82-2
[6-(4-{1-ethyl-1-[3-methyl-4-(4, 4, 4-trifluoro-3-hydroxy-3-trifluoromethyl-butyl)-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1.33 h

2: pyridine / dichloromethane / 0.5 h / -10 °C

3: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C

4: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

5: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

6: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.12 h / 140 °C / Irradiation

With pyridine; potassium phosphate; hydrogen; potassium acetate; potassium carbonate; trifluoroacetic acid; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 865235-98-9
4-{1-ethyl-1-[3-methyl-4-(4,4,4-trifluoro-3-methoxymethoxy-3-trifluoromethyl-1-butynyl)phenyl]propyl}-2-methylphenol

: 917025-82-2
[6-(4-{1-ethyl-1-[3-methyl-4-(4, 4, 4-trifluoro-3-hydroxy-3-trifluoromethyl-butyl)-phenyl]-propyl}-2-methyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 0.5 h / -10 °C

2: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C

3: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

4: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

5: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.12 h / 140 °C / Irradiation

With pyridine; potassium phosphate; hydrogen; potassium acetate; trifluoroacetic acid; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;