3-iodo-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine-6-carbonitrile

Base Information

Chemical Name:3-iodo-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine-6-carbonitrile
CAS No.:1347759-24-3
Molecular Formula:C₃₁H₂₅IN₄O₂
Molecular Weight:612.47
Hs Code.:

Synonyms:3-iodo-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine-6-carbonitrile

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Chemical Property of 3-iodo-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine-6-carbonitrile

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Technology Process of 3-iodo-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine-6-carbonitrile

There total 9 articles about 3-iodo-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1347759-23-2
3-iodo-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine-6-carbaldehyde

: 1347759-24-3
3-iodo-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine-6-carbonitrile

Guidance literature:: With hydroxylamine hydrochloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

: 138642-40-7
methyl 2,4-dichloro-6-methylpyridine-3-carboxylate

: 1347759-24-3
3-iodo-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine-6-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 °C

1.2: -78 - 20 °C

2.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 - 20 °C

3.1: hydrazine hydrate / 1,2-dimethoxyethane / 16 h / 80 °C

4.1: potassium hydroxide; iodine / 1,4-dioxane / 4 h / 70 °C

5.1: triethylamine / dichloromethane / 3.08 h / 20 °C

6.1: sodium hydride / 1,4-dioxane; mineral oil / 0.17 h

6.2: 1 h / 180 °C / Microwave irradiation

7.1: selenium(IV) oxide / 1,4-dioxane / 23 h / 100 °C

8.1: hydroxylamine hydrochloride; triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 2 h / 100 °C

With selenium(IV) oxide; oxalyl dichloride; hydroxylamine hydrochloride; iodine; sodium hydride; diisobutylaluminium hydride; hydrazine hydrate; dimethyl sulfoxide; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; potassium hydroxide; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 374800-25-6
2,4-Dichloro-3-hydroxymethyl-6-methylpyridine

: 1347759-24-3
3-iodo-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine-6-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 - 20 °C

2.1: hydrazine hydrate / 1,2-dimethoxyethane / 16 h / 80 °C

3.1: potassium hydroxide; iodine / 1,4-dioxane / 4 h / 70 °C

4.1: triethylamine / dichloromethane / 3.08 h / 20 °C

5.1: sodium hydride / 1,4-dioxane; mineral oil / 0.17 h

5.2: 1 h / 180 °C / Microwave irradiation

6.1: selenium(IV) oxide / 1,4-dioxane / 23 h / 100 °C

7.1: hydroxylamine hydrochloride; triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 2 h / 100 °C

With selenium(IV) oxide; oxalyl dichloride; hydroxylamine hydrochloride; iodine; sodium hydride; hydrazine hydrate; dimethyl sulfoxide; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; potassium hydroxide; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; mineral oil;