5-(4-cyanophenyl)-N-(4-hydroxypiperidin-1-yl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Base Information

Chemical Name:5-(4-cyanophenyl)-N-(4-hydroxypiperidin-1-yl)-6-(2,2,2-trifluoroethoxy)nicotinamide
CAS No.:1427064-47-8
Molecular Formula:C₂₀H₁₉F₃N₄O₃
Molecular Weight:420.391
Hs Code.:

Synonyms:5-(4-cyanophenyl)-N-(4-hydroxypiperidin-1-yl)-6-(2,2,2-trifluoroethoxy)nicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-cyanophenyl)-N-(4-hydroxypiperidin-1-yl)-6-(2,2,2-trifluoroethoxy)nicotinamide

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Technology Process of 5-(4-cyanophenyl)-N-(4-hydroxypiperidin-1-yl)-6-(2,2,2-trifluoroethoxy)nicotinamide

There total 4 articles about 5-(4-cyanophenyl)-N-(4-hydroxypiperidin-1-yl)-6-(2,2,2-trifluoroethoxy)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79414-82-7
1-aminopiperidin-4-ol

: 1364678-39-6
5-(4-cyanophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid

: 1427064-47-8
5-(4-cyanophenyl)-N-(4-hydroxypiperidin-1-yl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 850623-36-8
potassium (4-cyanophenyl)trifluoroborate

: 1427064-47-8
5-(4-cyanophenyl)-N-(4-hydroxypiperidin-1-yl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; palladium diacetate; catacxium A / toluene; water / 5 h / 120 °C / Inert atmosphere

2: lithium hydroxide / water; tetrahydrofuran / 3 h / 40 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 20 °C

With palladium diacetate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; catacxium A; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1211589-51-3
5-bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester

: 1427064-47-8
5-(4-cyanophenyl)-N-(4-hydroxypiperidin-1-yl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; palladium diacetate; catacxium A / toluene; water / 5 h / 120 °C / Inert atmosphere

2: lithium hydroxide / water; tetrahydrofuran / 3 h / 40 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 20 °C

With palladium diacetate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; catacxium A; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;