5-(4-cyanophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester

Base Information

Chemical Name:5-(4-cyanophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester
CAS No.:1427064-93-4
Molecular Formula:C₁₆H₁₁F₃N₂O₃
Molecular Weight:336.27
Hs Code.:

Synonyms:5-(4-cyanophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester

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Chemical Property of 5-(4-cyanophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester

Chemical Property:

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Technology Process of 5-(4-cyanophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester

There total 1 articles about 5-(4-cyanophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 850623-36-8
potassium (4-cyanophenyl)trifluoroborate

: 1211589-51-3
5-bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester

: 1427064-93-4
5-(4-cyanophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester

Guidance literature:: With di-(1-adamantyl)-n-butylphosphine; palladium diacetate; caesium carbonate; In water; toluene; at 120 ℃; for 5h; Inert atmosphere;

Reference yield:

: 1427064-93-4
5-(4-cyanophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester

: 1364678-39-6
5-(4-cyanophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 40 ℃; for 3h;

Reference yield:

: 1427064-93-4
5-(4-cyanophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid methyl ester

: 1427064-47-8
5-(4-cyanophenyl)-N-(4-hydroxypiperidin-1-yl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / water; tetrahydrofuran / 3 h / 40 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;