(2R,3S,9S,10R)-12-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-1-(4-methoxy-benzyloxy)-9-methyl-2,10-bis-triethylsilanyloxy-dodec-7-yn-6-one

Base Information

Chemical Name:(2R,3S,9S,10R)-12-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-1-(4-methoxy-benzyloxy)-9-methyl-2,10-bis-triethylsilanyloxy-dodec-7-yn-6-one
CAS No.:902453-80-9
Molecular Formula:C₄₀H₇₄O₇Si₃
Molecular Weight:751.28
Hs Code.:

Synonyms:(2R,3S,9S,10R)-12-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-1-(4-methoxy-benzyloxy)-9-methyl-2,10-bis-triethylsilanyloxy-dodec-7-yn-6-one

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Chemical Property of (2R,3S,9S,10R)-12-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-1-(4-methoxy-benzyloxy)-9-methyl-2,10-bis-triethylsilanyloxy-dodec-7-yn-6-one

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Technology Process of (2R,3S,9S,10R)-12-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-1-(4-methoxy-benzyloxy)-9-methyl-2,10-bis-triethylsilanyloxy-dodec-7-yn-6-one

There total 10 articles about (2R,3S,9S,10R)-12-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-1-(4-methoxy-benzyloxy)-9-methyl-2,10-bis-triethylsilanyloxy-dodec-7-yn-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 902453-74-1
(3S,4R)-6-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-4-triethylsilanyloxy-hex-1-yne

: 902453-75-2
(4S,5R)-4-Methoxy-6-(4-methoxy-benzyloxy)-5-triethylsilanyloxy-hexanoic acid methoxy-methyl-amide

: 902453-80-9
(2R,3S,9S,10R)-12-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-1-(4-methoxy-benzyloxy)-9-methyl-2,10-bis-triethylsilanyloxy-dodec-7-yn-6-one

Guidance literature:: (3S,4R)-6-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-4-triethylsilanyloxy-hex-1-yne; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 0.166667h;

(4S,5R)-4-Methoxy-6-(4-methoxy-benzyloxy)-5-triethylsilanyloxy-hexanoic acid methoxy-methyl-amide; In tetrahydrofuran; hexane; at 20 ℃; for 1.5h;
DOI:10.1055/s-2006-933144

Reference yield:

: 994-30-9
triethylsilyl chloride

: 902453-80-9
(2R,3S,9S,10R)-12-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-1-(4-methoxy-benzyloxy)-9-methyl-2,10-bis-triethylsilanyloxy-dodec-7-yn-6-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: imidazole / dimethylformamide

2.1: 73 percent / Ru(Co)12

3.1: 92 percent / i-PrMgCl / HCl; tetrahydrofuran

4.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / 20 °C

4.2: 82 percent / tetrahydrofuran; hexane / 1.5 h / 20 °C

With 1H-imidazole; n-butyllithium; isopropylmagnesium chloride; Ru(CO)12; In tetrahydrofuran; hydrogenchloride; hexane; N,N-dimethyl-formamide;
DOI:10.1055/s-2006-933144

Reference yield:

: 902453-84-3
(2R,3S)-3-Methoxy-1-(4-methoxy-benzyloxy)-pent-4-en-2-ol

: 902453-80-9
(2R,3S,9S,10R)-12-(tert-Butyl-dimethyl-silanyloxy)-3-methoxy-1-(4-methoxy-benzyloxy)-9-methyl-2,10-bis-triethylsilanyloxy-dodec-7-yn-6-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: imidazole / dimethylformamide

2.1: 73 percent / Ru(Co)12

3.1: 92 percent / i-PrMgCl / HCl; tetrahydrofuran

4.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / 20 °C

4.2: 82 percent / tetrahydrofuran; hexane / 1.5 h / 20 °C

With 1H-imidazole; n-butyllithium; isopropylmagnesium chloride; Ru(CO)12; In tetrahydrofuran; hydrogenchloride; hexane; N,N-dimethyl-formamide;
DOI:10.1055/s-2006-933144