Methyl 2-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazine-8-carboxylate

Base Information

Chemical Name:Methyl 2-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazine-8-carboxylate
CAS No.:1205747-90-5
Molecular Formula:C₂₅H₂₄ClN₃O₂
Molecular Weight:433.937
Hs Code.:

Synonyms:Methyl 2-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazine-8-carboxylate

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Chemical Property of Methyl 2-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazine-8-carboxylate

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Technology Process of Methyl 2-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazine-8-carboxylate

There total 12 articles about Methyl 2-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Methyl 1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazine-8-carboxylate dihydrochloride

: 854234-88-1
1-chloro-4-[2-(chloromethyl)phenyl]benzene

: 1205747-90-5
Methyl 2-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazine-8-carboxylate

Guidance literature:: With triethylamine; sodium iodide; In N,N-dimethyl-formamide; at 50 ℃; for 3h;

Reference yield:

: 23056-33-9
2-chloro-4-methyl-5-nitro-pyridine

: 1205747-90-5
Methyl 2-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazine-8-carboxylate

Guidance literature:: Multi-step reaction with 12 steps

1.1: methanol / 5 h / Reflux

2.1: potassium tert-butylate / diethyl ether; ethanol / 0.25 h

2.2: Reflux

2.3: 2 h / 20 °C

3.1: hydrogen / palladium on carbon / ethanol / 24 h

4.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

4.2: 24 h

5.1: hydrogenchloride / ethanol / 8 h / Reflux

6.1: phosphorus pentachloride / tetrahydrofuran / 2 h / 0 °C

6.2: 12 h / 20 °C

6.3: 10 h / Reflux

7.1: sodium hydride / N,N-dimethyl-formamide / 6 h / 0 - 20 °C

7.2: 17 h

8.1: lithium aluminium tetrahydride / toluene; tetrahydrofuran / 6 h / Reflux

8.2: 6 h / 0 - 20 °C

9.1: hydrogen bromide / acetic acid / 3 h / Reflux

9.2: 0 - 20 °C

9.3: 16 h / 0 - 20 °C

10.1: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / dimethyl sulfoxide / 18 h / 65 °C

11.1: hydrogenchloride / 20 wt% Pd(OH)2/C / methanol / 16 h

12.1: triethylamine; sodium iodide / N,N-dimethyl-formamide / 3 h / 50 °C

With hydrogenchloride; dmap; lithium aluminium tetrahydride; phosphorus pentachloride; potassium tert-butylate; hydrogen bromide; hydrogen; sodium hydride; triethylamine; sodium iodide; 1,1'-bis-(diphenylphosphino)ferrocene; palladium on carbon; 20 wt% Pd(OH)2/C; palladium diacetate; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1205747-85-8
2-Benzyl-8-methoxy-2,3,10,10a-tetrahydropyrido[4',3':4,5]pyrrolo[1,2-a]-pyrazine-1,4-dione

: 1205747-90-5
Methyl 2-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazine-8-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / toluene; tetrahydrofuran / 6 h / Reflux

1.2: 6 h / 0 - 20 °C

2.1: hydrogen bromide / acetic acid / 3 h / Reflux

2.2: 0 - 20 °C

2.3: 16 h / 0 - 20 °C

3.1: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / dimethyl sulfoxide / 18 h / 65 °C

4.1: hydrogenchloride / 20 wt% Pd(OH)2/C / methanol / 16 h

5.1: triethylamine; sodium iodide / N,N-dimethyl-formamide / 3 h / 50 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen bromide; triethylamine; sodium iodide; 1,1'-bis-(diphenylphosphino)ferrocene; 20 wt% Pd(OH)2/C; palladium diacetate; In tetrahydrofuran; methanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;