(4R,2E)-4-(3-bromophenyl)-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)but-2-enyl ethyl carbonate

Base Information

• Chemical Name: (4R,2E)-4-(3-bromophenyl)-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)but-2-enyl ethyl carbonate
• CAS No.: 1196033-52-9
• Molecular Formula: C₁₉H₂₁BrO₇
• Molecular Weight: 441.276
• Mol file: 1196033-52-9.mol

Synonyms:(4R,2E)-4-(3-bromophenyl)-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)but-2-enyl ethyl carbonate

Chemical Property of (4R,2E)-4-(3-bromophenyl)-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)but-2-enyl ethyl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,2E)-4-(3-bromophenyl)-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)but-2-enyl ethyl carbonate

There total 1 articles about (4R,2E)-4-(3-bromophenyl)-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)but-2-enyl ethyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-(3-bromobenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (15795-60-5) + ethyl [(E)-3-(1,1,1-tributylstannyl)-2-propenyl] carbonate (1007392-16-6) → (4R,2E)-4-(3-bromophenyl)-4-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)but-2-enyl ethyl carbonate (1196033-52-9)

Guidance literature:

With silver hexafluoroantimonate; chlorobis(ethylene)rhodium(I) dimer; 5-methoxy-1,5-dimethyl-2-(2-(trifluoromethyl)phenyl)bicyclo[2.2.2]octa-2,7-diene; In tetrahydrofuran; at 10 ℃; for 45h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1021/ol902216y

upstream raw materials:

5-(3-bromobenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

ethyl [(E)-3-(1,1,1-tributylstannyl)-2-propenyl] carbonate