4-((4-(2-(6-(1H-tetrazol-5-yl)pyridin-3-yl)cyclopropyl)-3-chlorophenoxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole

Base Information

Chemical Name:4-((4-(2-(6-(1H-tetrazol-5-yl)pyridin-3-yl)cyclopropyl)-3-chlorophenoxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole
CAS No.:1268245-14-2
Molecular Formula:C₂₈H₂₁Cl₃N₆O₂
Molecular Weight:579.873
Hs Code.:

Synonyms:4-((4-(2-(6-(1H-tetrazol-5-yl)pyridin-3-yl)cyclopropyl)-3-chlorophenoxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole

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Chemical Property of 4-((4-(2-(6-(1H-tetrazol-5-yl)pyridin-3-yl)cyclopropyl)-3-chlorophenoxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole

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Technology Process of 4-((4-(2-(6-(1H-tetrazol-5-yl)pyridin-3-yl)cyclopropyl)-3-chlorophenoxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole

There total 19 articles about 4-((4-(2-(6-(1H-tetrazol-5-yl)pyridin-3-yl)cyclopropyl)-3-chlorophenoxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.2%

: C₂₈H₂₀Cl₃N₃O₂

: 1268245-14-2
4-((4-(2-(6-(1H-tetrazol-5-yl)pyridin-3-yl)cyclopropyl)-3-chlorophenoxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 100 ℃;

Reference yield:

: 1620-77-5
5-methylpicolinonitrile

: 1268245-14-2
4-((4-(2-(6-(1H-tetrazol-5-yl)pyridin-3-yl)cyclopropyl)-3-chlorophenoxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 2 h / Reflux

2.1: 4 h / 175 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 0 - 20 °C

4.1: palladium diacetate / diethyl ether / -50 - 20 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

5.2: 20 °C

6.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 100 °C

With N-Bromosuccinimide; sodium azide; sodium hydride; ammonium chloride; palladium diacetate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; diethyl ether; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 108-43-0
3-monochlorophenol

: 1268245-14-2
4-((4-(2-(6-(1H-tetrazol-5-yl)pyridin-3-yl)cyclopropyl)-3-chlorophenoxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; sodium carbonate; calcium hydroxide / 4.33 h / Inert atmosphere; Reflux

2.1: triethylamine / dmap / dichloromethane / 1 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 0 - 20 °C

4.1: palladium diacetate / diethyl ether / -50 - 20 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

5.2: 20 °C

6.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 100 °C

With sodium azide; water; sodium hydride; sodium carbonate; ammonium chloride; triethylamine; calcium hydroxide; dmap; palladium diacetate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;