phenyl(3-phenyloxiran-2-yl)methanol

Base Information

• Chemical Name: phenyl(3-phenyloxiran-2-yl)methanol
• CAS No.: 38860-42-3
• Molecular Formula: C₁₅H₁₄O₂
• Molecular Weight: 226.275
• Mol file: 38860-42-3.mol

Synonyms:phenyl(3-phenyloxiran-2-yl)methanol

Chemical Property of phenyl(3-phenyloxiran-2-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of phenyl(3-phenyloxiran-2-yl)methanol

There total 18 articles about phenyl(3-phenyloxiran-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(2Z)-1,3-diphenyl-2-propen-1-ol (62839-70-7,1003558-27-7) → cis-2,3-epoxy-1,3-diphenylpropan-1-ol (26553-43-5,26553-44-6,38860-42-3,88335-63-1,88335-64-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1.) 0 deg C, 30 min; 2.) room temperature, 12 h;

DOI:10.1039/P29860000923

Reference yield: 88.0%

chalcone epoxide (5411-12-1) → phenyl(3-phenyloxiran-2-yl)methanol (38860-42-3)

Guidance literature:

With ammonium chloride; zinc; In tetrahydrofuran; water; at 60 ℃; for 3h;

DOI:10.1002/ejoc.201700887

Reference yield: 76.0%

(E)-1,3-diphenyl-2-propen-1-ol (62668-02-4) → phenyl(3-phenyloxiran-2-yl)methanol (38860-42-3)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; 5-hydro-3-oxaoctafluoropentanesulfonyl fluoride; In methanol; at 20 ℃; for 8h;

DOI:10.1016/j.tetlet.2004.01.054

upstream raw materials:

(2Z)-1,3-diphenyl-2-propen-1-ol

tri-n-butyl(cis-epoxystyryl)tin

benzaldehyde

(E)-1,3-diphenyl-2-propen-1-ol

Downstream raw materials:

(E)-1-Phenyl-2-(phenylmethoxy)ethene

(Z)-1-Phenyl-2-(phenylmethoxy)ethene

(2S,3R)-phenyl(3-phenyloxiran-2-yl)methanone

trans-(2S,3R)-epoxy-1,3-diphenylpropan-1-one

Refernces

• 1、 Mandal, Tirtha,Jana, Snehasish,Dash, Jyotirmayee. "Zinc-Mediated Efficient and Selective Reduction of Carbonyl Compounds". . p. 4972 - 4983. Retrieved 2017/09/13.
• 2、 Infante, Rebeca,Hernandez, Yulan,Nieto, Javier,Andres, Celia. "Enantioselective one-pot catalytic synthesis of 4,5-epoxy-3-alkanols and 1-Phenyl-2,3-epoxy-1-alkanols from α,β-unsaturated aldehydes". . p. 4863 - 4869. Retrieved 2013/08/23.