5-[[4-(2H-tetrazol-5-yl)phenyl]methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone

Base Information

Chemical Name:5-[[4-(2H-tetrazol-5-yl)phenyl]methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone
CAS No.:1073612-53-9
Molecular Formula:C₁₈H₁₀F₃N₅OS₂
Molecular Weight:433.438
Hs Code.:

Synonyms:5-[[4-(2H-tetrazol-5-yl)phenyl]methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone

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Chemical Property of 5-[[4-(2H-tetrazol-5-yl)phenyl]methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone

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Technology Process of 5-[[4-(2H-tetrazol-5-yl)phenyl]methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone

There total 5 articles about 5-[[4-(2H-tetrazol-5-yl)phenyl]methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 315-08-2
2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone

: 74815-22-8
4-(1H-1,2,3,4-tetrazol-5-yl)benzaldehyde

: 1073612-53-9
5-[[4-(2H-tetrazol-5-yl)phenyl]methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone

Guidance literature:: piperidine; for 0.5h; Reflux;

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 1073612-53-9
5-[[4-(2H-tetrazol-5-yl)phenyl]methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / ethyl acetate / Cooling with ice

2.1: sodium hydrogencarbonate / water / 2 h / pH 8 - 9

2.2: Reflux

3.1: piperidine / 0.5 h / Reflux

With sodium hydrogencarbonate; triethylamine; piperidine; In water; ethyl acetate;

Reference yield:

: 1840-19-3
1-isothiocyanato-3-trifluoromethyl-benzene

: 1073612-53-9
5-[[4-(2H-tetrazol-5-yl)phenyl]methylene]-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / water; tetrahydrofuran / 3.5 h / 0 - 20 °C

1.2: Reflux

2.1: piperidine / 0.5 h / Reflux

With triethylamine; piperidine; In tetrahydrofuran; water;