2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde

Base Information

• Chemical Name: 2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde
• CAS No.: 80774-14-7
• Molecular Formula: C₁₂H₆F₃N₃OS
• Molecular Weight: 297.26

Synonyms:2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde

Chemical Property of 2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde

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Technology Process of 2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde

There total 1 articles about 2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole → 2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde (80774-14-7)

Guidance literature:

With trichlorophosphate; at 0 - 60 ℃; for 4.5h;

DOI:10.1016/j.bmcl.2012.01.052

Reference yield: 70.0%

2-thioxo-4-thiazolidinone (141-84-4) + 2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde (80774-14-7) → 5-((2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methylene)-2-thioxothiazolidin-4-one (1365994-51-9)

Guidance literature:

With piperidinyl acetate; Neat (no solvent); Microwave irradiation;

DOI:10.1016/j.bmcl.2012.01.052

Reference yield: 69.0%

thiazoline-2,4-dione (2295-31-0) + 2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole-5-carbaldehyde (80774-14-7) → 5-((2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methylene)thiazolidine-2,4-dione (1365994-42-8)

Guidance literature:

With piperidinyl acetate; for 0.166667h; Neat (no solvent); Microwave irradiation;

DOI:10.1016/j.bmcl.2012.01.052

upstream raw materials:

N,N-dimethyl-formamide

Downstream raw materials:

5-((2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methylene)thiazolidine-2,4-dione

5-((2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methylene)-2-thioxothiazolidin-4-one

2-((5Z)-5-((2-(trifluoromethyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid

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