Methanesulfonic acid (S)-1-((2R,7S)-7-benzyloxymethyl-oxepan-2-yl)-2-(4-methoxy-benzyloxy)-ethyl ester

Base Information

Chemical Name:Methanesulfonic acid (S)-1-((2R,7S)-7-benzyloxymethyl-oxepan-2-yl)-2-(4-methoxy-benzyloxy)-ethyl ester
CAS No.:313677-56-4
Molecular Formula:C₂₅H₃₄O₇S
Molecular Weight:478.607
Hs Code.:

Synonyms:Methanesulfonic acid (S)-1-((2R,7S)-7-benzyloxymethyl-oxepan-2-yl)-2-(4-methoxy-benzyloxy)-ethyl ester

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Chemical Property of Methanesulfonic acid (S)-1-((2R,7S)-7-benzyloxymethyl-oxepan-2-yl)-2-(4-methoxy-benzyloxy)-ethyl ester

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Technology Process of Methanesulfonic acid (S)-1-((2R,7S)-7-benzyloxymethyl-oxepan-2-yl)-2-(4-methoxy-benzyloxy)-ethyl ester

There total 10 articles about Methanesulfonic acid (S)-1-((2R,7S)-7-benzyloxymethyl-oxepan-2-yl)-2-(4-methoxy-benzyloxy)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124-63-0
methanesulfonyl chloride

: 313677-42-8
(S)-1-((2R,7S)-7-Benzyloxymethyl-oxepan-2-yl)-2-(4-methoxy-benzyloxy)-ethanol

: 313677-56-4
Methanesulfonic acid (S)-1-((2R,7S)-7-benzyloxymethyl-oxepan-2-yl)-2-(4-methoxy-benzyloxy)-ethyl ester

Guidance literature:: With dmap; TEA; In dichloromethane;
DOI:10.1016/S0040-4039(00)01344-7

Reference yield:

: 124662-63-1
(S)-5-Benzyloxy-4-tert-butyldimethylsiloxy-1-pentyne

: 313677-56-4
Methanesulfonic acid (S)-1-((2R,7S)-7-benzyloxymethyl-oxepan-2-yl)-2-(4-methoxy-benzyloxy)-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi; HMPA / tetrahydrofuran / -30 °C

2.1: TBAF / tetrahydrofuran

3.1: 78 percent / H₂ / Pd-C / ethyl acetate

4.1: (Bu₃Sn)2O / toluene / Heating

4.2: 85 percent / Zn(OTf)2 / toluene / 10 h / 90 °C

5.1: 99 percent / TEA; DMAP / CH₂Cl₂

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; TEA; tetrabutyl ammonium fluoride; hydrogen; bis(tri-n-butyltin)oxide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene; 1.1: Alkylation / 2.1: Substitution / 3.1: Catalytic hydrogenation / 4.1: Etherification / 4.2: Cyclization / 5.1: mesylation;
DOI:10.1016/S0040-4039(00)01344-7

Reference yield:

: 124662-61-9
(S)-5-Benzyloxy-4-hydroxy-1-pentyne

: 313677-56-4
Methanesulfonic acid (S)-1-((2R,7S)-7-benzyloxymethyl-oxepan-2-yl)-2-(4-methoxy-benzyloxy)-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 100 percent / NaH / tetrahydrofuran

2.1: n-BuLi; HMPA / tetrahydrofuran / -30 °C

3.1: TBAF / tetrahydrofuran

4.1: 78 percent / H₂ / Pd-C / ethyl acetate

5.1: (Bu₃Sn)2O / toluene / Heating

5.2: 85 percent / Zn(OTf)2 / toluene / 10 h / 90 °C

6.1: 99 percent / TEA; DMAP / CH₂Cl₂

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; TEA; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; bis(tri-n-butyltin)oxide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene; 1.1: Etherification / 2.1: Alkylation / 3.1: Substitution / 4.1: Catalytic hydrogenation / 5.1: Etherification / 5.2: Cyclization / 6.1: mesylation;
DOI:10.1016/S0040-4039(00)01344-7