4-(2-furanyl)-2-methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole

Base Information

Chemical Name:4-(2-furanyl)-2-methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole
CAS No.:1372540-83-4
Molecular Formula:C₂₅H₂₄F₃N₃O₂
Molecular Weight:455.48
Hs Code.:

Synonyms:4-(2-furanyl)-2-methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole

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Chemical Property of 4-(2-furanyl)-2-methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole

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Technology Process of 4-(2-furanyl)-2-methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole

There total 9 articles about 4-(2-furanyl)-2-methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.43%

: 13331-23-2
fur-2-ylboronic acid

: 1372540-63-0
4-(7-bromo-2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-3H-benzo[d]imidazol-5-yl)morpholine

: 1372540-83-4
4-(2-furanyl)-2-methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 100 ℃; for 1h; microwave irradiation;

Reference yield:

: 606-22-4
2,6-dinitroaniline

: 1372540-83-4
4-(2-furanyl)-2-methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 9 steps

1.1: bromine / acetic acid / 2 h / 120 °C

2.1: diammonium sulfide / ethanol / 2 h / 90 °C

3.1: ethanol; water / 3 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

5.1: caesium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / 1,4-dioxane / 4 h / 82 °C / Inert atmosphere

6.1: hydrogen / palladium on activated charcoal / ethanol / 50 h / 60 °C / 3040.2 Torr

7.1: water; sodium nitrite; hydrogen bromide / 0.08 h / 0 - 5 °C

7.2: 0.5 h / 60 - 80 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

8.2: 3 h / 80 °C

9.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 1 h / 100 °C / microwave irradiation

With diammonium sulfide; water; hydrogen bromide; hydrogen; bromine; sodium carbonate; potassium carbonate; caesium carbonate; sodium nitrite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 84752-20-5
4-bromo-6-nitro-1,2-phenylenediamine

: 1372540-83-4
4-(2-furanyl)-2-methyl-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethanol; water / 3 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

3.1: caesium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / 1,4-dioxane / 4 h / 82 °C / Inert atmosphere

4.1: hydrogen / palladium on activated charcoal / ethanol / 50 h / 60 °C / 3040.2 Torr

5.1: water; sodium nitrite; hydrogen bromide / 0.08 h / 0 - 5 °C

5.2: 0.5 h / 60 - 80 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

6.2: 3 h / 80 °C

7.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 1 h / 100 °C / microwave irradiation

With water; hydrogen bromide; hydrogen; sodium carbonate; potassium carbonate; caesium carbonate; sodium nitrite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;