6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

Base Information

Chemical Name:6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide
CAS No.:1423007-30-0
Molecular Formula:C₂₆H₂₁BrClFN₂O₄S
Molecular Weight:591.885
Hs Code.:

Synonyms:6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

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Chemical Property of 6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

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Technology Process of 6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

There total 14 articles about 6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1423007-29-7
6-[N-(4-amino-3-chlorophenyl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

: 1423007-30-0
6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

Guidance literature:: 6-[N-(4-amino-3-chlorophenyl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide; With hydrogen bromide; In water; acetonitrile; for 1h; Cooling with ice;

With sodium nitrite; In water; acetonitrile; for 1.58333h; Cooling with ice;

With copper(I) bromide; In water; acetonitrile; at 60 ℃; for 0.75h;

Reference yield:

: 691856-35-6
5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide

: 1423007-30-0
6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / water; 1,2-dimethoxyethane / 88 h / 20 - 100 °C / Sealed tube

2.1: hydrogen; 5 % platinum carbon sulfide / tetrahydrofuran; methanol / 40 h / 2068.65 Torr

3.1: hydrogen bromide / acetonitrile; water / 1 h / Cooling with ice

3.2: 1.58 h / Cooling with ice

3.3: 0.75 h / 60 °C

With 5 % platinum carbon sulfide; hydrogen bromide; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; acetonitrile; 3.1: |Sandmeyer Reaction;

Reference yield:

: 1423007-28-6
6-[N-(3-chloro-4-nitrophenyl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

: 1423007-30-0
6-[N-(4-bromo-3-chlorophenyl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen; 5 % platinum carbon sulfide / tetrahydrofuran; methanol / 40 h / 2068.65 Torr

2.1: hydrogen bromide / acetonitrile; water / 1 h / Cooling with ice

2.2: 1.58 h / Cooling with ice

2.3: 0.75 h / 60 °C

With 5 % platinum carbon sulfide; hydrogen bromide; hydrogen; In tetrahydrofuran; methanol; water; acetonitrile; 2.1: |Sandmeyer Reaction;