Technology Process of 3-benzyl-5-(2-oxo-2H-pyridin-1-ylmethyl)-1-bromobenzene
There total 7 articles about 3-benzyl-5-(2-oxo-2H-pyridin-1-ylmethyl)-1-bromobenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
DMF (N,N-dimethyl-formamide);
at 110 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / hexanes; diethyl ether / 0.5 h / -78 °C
1.2: -78 - 0 °C
2.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 20 °C
3.1: tetrahydrofuran; hexanes / 1 h / -78 °C
3.2: -78 - 20 °C
4.1: sodium tetrahydroborate / methanol / 3 h / 20 °C
5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C
6.1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 2 h / 110 °C
With
triethylsilane; sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; boron trifluoride diethyl etherate; caesium carbonate; triphenylphosphine;
In
tetrahydrofuran; methanol; hexanes; DMF (N,N-dimethyl-formamide); diethyl ether; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrahydrofuran; hexanes / 1 h / -78 °C
1.2: -78 - 20 °C
2.1: sodium tetrahydroborate / methanol / 3 h / 20 °C
3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C
4.1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 2 h / 110 °C
With
sodium tetrahydroborate; carbon tetrabromide; caesium carbonate; triphenylphosphine;
In
tetrahydrofuran; methanol; hexanes; DMF (N,N-dimethyl-formamide); dichloromethane;
