1-[3-benzyl-5-(2-oxo-2H-pyridin-1-ylmethyl)phenyl]-3-(4-methylpyridin-2-yl)-propane-1,3-dione

Base Information

Chemical Name:1-[3-benzyl-5-(2-oxo-2H-pyridin-1-ylmethyl)phenyl]-3-(4-methylpyridin-2-yl)-propane-1,3-dione
CAS No.:317332-80-2
Molecular Formula:C₂₈H₂₄N₂O₃
Molecular Weight:436.51
Hs Code.:

Synonyms:1-[3-benzyl-5-(2-oxo-2H-pyridin-1-ylmethyl)phenyl]-3-(4-methylpyridin-2-yl)-propane-1,3-dione

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Chemical Property of 1-[3-benzyl-5-(2-oxo-2H-pyridin-1-ylmethyl)phenyl]-3-(4-methylpyridin-2-yl)-propane-1,3-dione

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Technology Process of 1-[3-benzyl-5-(2-oxo-2H-pyridin-1-ylmethyl)phenyl]-3-(4-methylpyridin-2-yl)-propane-1,3-dione

There total 11 articles about 1-[3-benzyl-5-(2-oxo-2H-pyridin-1-ylmethyl)phenyl]-3-(4-methylpyridin-2-yl)-propane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13509-13-2
4-methylpyridine-2-carboxylic acid methyl ester

: 317334-62-6
3-benzyl-5-(2-oxo-2H-pyridin-1-ylmethyl)acetophenone

: 317332-80-2
1-[3-benzyl-5-(2-oxo-2H-pyridin-1-ylmethyl)phenyl]-3-(4-methylpyridin-2-yl)-propane-1,3-dione

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.25h;

Reference yield:

: 317334-61-5
3-benzyl-5-(2-oxo-2H-pyridin-1-ylmethyl)-1-bromobenzene

: 317332-80-2
1-[3-benzyl-5-(2-oxo-2H-pyridin-1-ylmethyl)phenyl]-3-(4-methylpyridin-2-yl)-propane-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: -butyl vinyl ether; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / DMF (N,N-dimethyl-formamide) / 100 °C

1.2: 3 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C

With -butyl vinyl ether; sodium hydride; triethylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; DMF (N,N-dimethyl-formamide);

Reference yield:

: 626-39-1
1,3,5-trisbromobenzene

: 317332-80-2
1-[3-benzyl-5-(2-oxo-2H-pyridin-1-ylmethyl)phenyl]-3-(4-methylpyridin-2-yl)-propane-1,3-dione

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / hexanes; diethyl ether / 0.5 h / -78 °C

1.2: -78 - 0 °C

2.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 20 °C

3.1: tetrahydrofuran; hexanes / 1 h / -78 °C

3.2: -78 - 20 °C

4.1: sodium tetrahydroborate / methanol / 3 h / 20 °C

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C

6.1: caesium carbonate / DMF (N,N-dimethyl-formamide) / 2 h / 110 °C

7.1: -butyl vinyl ether; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / DMF (N,N-dimethyl-formamide) / 100 °C

7.2: 3 h / 20 °C

8.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C

With triethylsilane; sodium tetrahydroborate; n-butyllithium; -butyl vinyl ether; carbon tetrabromide; boron trifluoride diethyl etherate; sodium hydride; caesium carbonate; triethylamine; triphenylphosphine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; methanol; hexanes; DMF (N,N-dimethyl-formamide); diethyl ether; dichloromethane;