4’-deoxy-4’-fluoro-4’-epineamine

Base Information

Chemical Name:4’-deoxy-4’-fluoro-4’-epineamine
CAS No.:1624627-77-5
Molecular Formula:C₁₂H₂₅FN₄O₅
Molecular Weight:324.353
Hs Code.:

Synonyms:4’-deoxy-4’-fluoro-4’-epineamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4’-deoxy-4’-fluoro-4’-epineamine

Chemical Property:

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Technology Process of 4’-deoxy-4’-fluoro-4’-epineamine

There total 9 articles about 4’-deoxy-4’-fluoro-4’-epineamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1624627-61-7
C₃₃H₄₃FN₄O₅

: 1624627-77-5
4’-deoxy-4’-fluoro-4’-epineamine

Guidance literature:: With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; water; hydrogen; In methanol; at 22 - 26 ℃; for 10h; under 760.051 Torr; Inert atmosphere;
DOI:10.1039/c4md00072b

Reference yield:

: 1624627-55-9
1,3,2’-triazido-5,6,3’-tri-O-benzyl-4’,6’-O-benzylidene paromamine

: 1624627-77-5
4’-deoxy-4’-fluoro-4’-epineamine

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid; water / tetrahydrofuran / 60 °C / Inert atmosphere

2: pyridine / dichloromethane / 22 - 26 °C / Inert atmosphere

3: sodium azide / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere

4: diethylamino-sulfur trifluoride / dichloromethane / 22 - 26 °C / Inert atmosphere

5: trimethylphosphane; sodium hydroxide; water / tetrahydrofuran / 1 h / 50 °C / Inert atmosphere

6: hydrogenchloride; hydrogen; 10 wt% Pd(OH)2 on carbon; water / methanol / 10 h / 22 - 26 °C / 760.05 Torr / Inert atmosphere

With pyridine; hydrogenchloride; sodium azide; diethylamino-sulfur trifluoride; 10 wt% Pd(OH)2 on carbon; water; hydrogen; acetic acid; sodium hydroxide; trimethylphosphane; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 5: |Staudinger Azide Reduction;
DOI:10.1039/c4md00072b

Reference yield:

: 1624627-57-1
1,3,2’-triazido-5,6,3’-tri-O-benzyl-6’-O-(p-toluenesulfonyl)paromamine

: 1624627-77-5
4’-deoxy-4’-fluoro-4’-epineamine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere

2: diethylamino-sulfur trifluoride / dichloromethane / 22 - 26 °C / Inert atmosphere

3: trimethylphosphane; sodium hydroxide; water / tetrahydrofuran / 1 h / 50 °C / Inert atmosphere

4: hydrogenchloride; hydrogen; 10 wt% Pd(OH)2 on carbon; water / methanol / 10 h / 22 - 26 °C / 760.05 Torr / Inert atmosphere

With hydrogenchloride; sodium azide; diethylamino-sulfur trifluoride; 10 wt% Pd(OH)2 on carbon; water; hydrogen; sodium hydroxide; trimethylphosphane; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 3: |Staudinger Azide Reduction;
DOI:10.1039/c4md00072b