1'-(4-fluorobenzoyl)-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine]

Base Information

• Chemical Name: 1'-(4-fluorobenzoyl)-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine]
• CAS No.: 1167435-01-9
• Molecular Formula: C₂₀H₂₀FNO₃
• Molecular Weight: 341.382
• Mol file: 1167435-01-9.mol

Synonyms:1'-(4-fluorobenzoyl)-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine]

Chemical Property of 1'-(4-fluorobenzoyl)-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1'-(4-fluorobenzoyl)-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine]

There total 1 articles about 1'-(4-fluorobenzoyl)-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

C13H17NO2 (1167434-93-6) + 4-fluorobenzoyl chloride (403-43-0) → 1'-(4-fluorobenzoyl)-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine] (1167435-01-9)

Guidance literature:

C₁₃H₁₇NO₂; 4-fluorobenzoyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;

With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2009.03.060

Reference yield: 35.0%

1'-(4-fluorobenzoyl)-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine] (1167435-01-9) → 1'-(4-fluorobenzyl)-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine] (1167434-94-7)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; Inert atmosphere;

DOI:10.1016/j.bmc.2009.03.060

upstream raw materials:

C₁₃H₁₇NO₂

4-fluorobenzoyl chloride

Downstream raw materials:

1'-(4-fluorobenzyl)-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine]