3-fluorobenzyl-2,3,4,6-tetra-O-benzyl-D-galactonoamidine

Base Information

• Chemical Name: 3-fluorobenzyl-2,3,4,6-tetra-O-benzyl-D-galactonoamidine
• CAS No.: 1352436-22-6
• Molecular Formula: C₄₁H₄₁FN₂O₄
• Molecular Weight: 644.786
• Mol file: 1352436-22-6.mol

Synonyms:3-fluorobenzyl-2,3,4,6-tetra-O-benzyl-D-galactonoamidine

Chemical Property of 3-fluorobenzyl-2,3,4,6-tetra-O-benzyl-D-galactonoamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-fluorobenzyl-2,3,4,6-tetra-O-benzyl-D-galactonoamidine

There total 4 articles about 3-fluorobenzyl-2,3,4,6-tetra-O-benzyl-D-galactonoamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-fluorophenyl)methanamine (100-82-3) + C36H39NO4S (1309382-73-7) → 3-fluorobenzyl-2,3,4,6-tetra-O-benzyl-D-galactonoamidine (1352436-22-6)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.tet.2011.10.048

Reference yield:

(3-fluorophenyl)methanamine (100-82-3) + 2,3,4,6-tetra-O-benzyl-D-galactothionolactam (214784-10-8) → 3-fluorobenzyl-2,3,4,6-tetra-O-benzyl-D-galactonoamidine (1352436-22-6)

Guidance literature:

2,3,4,6-tetra-O-benzyl-D-galactothionolactam; With triethyloxonium fluoroborate; In dichloromethane; at 0 ℃; for 2h;

(3-fluorophenyl)methanamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm501111y

Reference yield:

(3R,4S,5S,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)piperidin-2-one (158349-25-8) → 3-fluorobenzyl-2,3,4,6-tetra-O-benzyl-D-galactonoamidine (1352436-22-6)

Guidance literature:

Multi-step reaction with 3 steps

1: Lawessons reagent / benzene / 2 h / Reflux

2: dichloromethane / 2 h / 0 °C

3: dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

With Lawessons reagent; In dichloromethane; benzene;

DOI:10.1016/j.tet.2011.10.048

upstream raw materials:

(3-fluorophenyl)methanamine

C₃₆H₃₉NO₄S

(3R,4S,5S,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)piperidin-2-one

2,3,4,6-tetra-O-benzyl-D-galactothionolactam

Downstream raw materials:

N-3-fluorobenzyl-D-galactonoamidine