(R)-tert-butyl 2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methoxy)acetate

Base Information

Chemical Name:(R)-tert-butyl 2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methoxy)acetate
CAS No.:1001054-48-3
Molecular Formula:C₂₂H₃₅NO₇S
Molecular Weight:457.588
Hs Code.:

Synonyms:(R)-tert-butyl 2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methoxy)acetate

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Chemical Property of (R)-tert-butyl 2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methoxy)acetate

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Technology Process of (R)-tert-butyl 2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methoxy)acetate

There total 3 articles about (R)-tert-butyl 2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1001054-47-2
(R)-(4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methanol

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1001054-48-3
(R)-tert-butyl 2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methoxy)acetate

Guidance literature:: With sodium hydride; potassium iodide; In ISOPROPYLAMIDE; at 20 ℃; for 48h;

Reference yield:

: 1001054-45-0
(S)-methyl 4-benzyl-6,6-dimethylmorpholine-3-carboxylate

: 1001054-48-3
(R)-tert-butyl 2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methoxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / Pd(OH)2/C / methanol; acetic acid / 35 h / 2585.81 Torr

2: dmap / pyridine / 5 h / 50 °C

3: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C

4: sodium hydride; potassium iodide / ISOPROPYLAMIDE / 48 h / 20 °C

With dmap; hydrogen; sodium hydride; diisobutylaluminium hydride; potassium iodide; Pd(OH)2/C; In tetrahydrofuran; pyridine; methanol; ISOPROPYLAMIDE; acetic acid;

Reference yield:

: 3-methyl 4-benzyl-6-(iodomethyl)-6-methylmorpholine-3-carboxylate

: 1001054-48-3
(R)-tert-butyl 2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 2 h / Heating / reflux

2: hydrogen / Pd(OH)2/C / methanol; acetic acid / 35 h / 2585.81 Torr

3: dmap / pyridine / 5 h / 50 °C

4: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C

5: sodium hydride; potassium iodide / ISOPROPYLAMIDE / 48 h / 20 °C

With dmap; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; sodium hydride; diisobutylaluminium hydride; potassium iodide; Pd(OH)2/C; In tetrahydrofuran; pyridine; methanol; ISOPROPYLAMIDE; acetic acid; toluene;