(R)-(4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methanol

Base Information

Chemical Name:(R)-(4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methanol
CAS No.:1001054-47-2
Molecular Formula:C₁₆H₂₅NO₅S
Molecular Weight:343.444
Hs Code.:

Synonyms:(R)-(4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methanol

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Chemical Property of (R)-(4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methanol

Chemical Property:

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Technology Process of (R)-(4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methanol

There total 3 articles about (R)-(4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1001054-46-1
(S)-methyl 4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholine-3-carboxylate

: 1001054-47-2
(R)-(4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methanol

Guidance literature:: (S)-methyl 4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholine-3-carboxylate; With diisobutylaluminium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

With sodium sulfate; In tetrahydrofuran;

Reference yield:

: 1001054-45-0
(S)-methyl 4-benzyl-6,6-dimethylmorpholine-3-carboxylate

: 1001054-47-2
(R)-(4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / Pd(OH)2/C / methanol; acetic acid / 35 h / 2585.81 Torr

2: dmap / pyridine / 5 h / 50 °C

3: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C

With dmap; hydrogen; diisobutylaluminium hydride; Pd(OH)2/C; In tetrahydrofuran; pyridine; methanol; acetic acid;

Reference yield:

: 3-methyl 4-benzyl-6-(iodomethyl)-6-methylmorpholine-3-carboxylate

: 1001054-47-2
(R)-(4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 2 h / Heating / reflux

2: hydrogen / Pd(OH)2/C / methanol; acetic acid / 35 h / 2585.81 Torr

3: dmap / pyridine / 5 h / 50 °C

4: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C

With dmap; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; diisobutylaluminium hydride; Pd(OH)2/C; In tetrahydrofuran; pyridine; methanol; acetic acid; toluene;