Technology Process of (R)-(4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methanol
There total 3 articles about (R)-(4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholin-3-yl)methanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-methyl 4-(4-methoxy-2,6-dimethylphenylsulfonyl)-6,6-dimethylmorpholine-3-carboxylate;
With
diisobutylaluminium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
With
sodium sulfate;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogen / Pd(OH)2/C / methanol; acetic acid / 35 h / 2585.81 Torr
2: dmap / pyridine / 5 h / 50 °C
3: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C
With
dmap; hydrogen; diisobutylaluminium hydride;
Pd(OH)2/C;
In
tetrahydrofuran; pyridine; methanol; acetic acid;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 2 h / Heating / reflux
2: hydrogen / Pd(OH)2/C / methanol; acetic acid / 35 h / 2585.81 Torr
3: dmap / pyridine / 5 h / 50 °C
4: diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 °C
With
dmap; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; diisobutylaluminium hydride;
Pd(OH)2/C;
In
tetrahydrofuran; pyridine; methanol; acetic acid; toluene;
