(R)-2-((tert-butoxycarbonyl)amino)-4-oxo-4-phenylbutanoic acid

Base Information

• Chemical Name: (R)-2-((tert-butoxycarbonyl)amino)-4-oxo-4-phenylbutanoic acid
• CAS No.: 1434254-07-5
• Molecular Formula: C₁₅H₁₉NO₅
• Molecular Weight: 293.32
• Mol file: 1434254-07-5.mol

Synonyms:(R)-2-((tert-butoxycarbonyl)amino)-4-oxo-4-phenylbutanoic acid

Chemical Property of (R)-2-((tert-butoxycarbonyl)amino)-4-oxo-4-phenylbutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (R)-2-((tert-butoxycarbonyl)amino)-4-oxo-4-phenylbutanoic acid

There total 12 articles about (R)-2-((tert-butoxycarbonyl)amino)-4-oxo-4-phenylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl (R)-3-benzoyl-2-((tert-butoxycarbonyl)amino)-4-oxo-4-phenylbutanoate → (R)-2-((tert-butoxycarbonyl)amino)-4-oxo-4-phenylbutanoic acid (1434254-07-5)

Guidance literature:

With silica gel; lithium hydroxide; In methanol; water; at 20 ℃; for 6h;

DOI:10.1039/d0cc06055k

Reference yield: 84.0%

(R)-3-(tert-butyloxycarbonylamino)-4-hydroxy-1-phenylbutan-1-one (1434253-99-2) → (R)-2-((tert-butoxycarbonyl)amino)-4-oxo-4-phenylbutanoic acid (1434254-07-5)

Guidance literature:

With dipyridinium dichromate; In N,N-dimethyl-formamide; at 30 ℃; for 15h;

DOI:10.1002/ejoc.201201128

Reference yield:

2-(tert-butyloxycarbonylamino)-3-(2-phenyl-1,3-dithian-2-yl)propan-1-ol (1434253-91-4) → (R)-2-((tert-butoxycarbonyl)amino)-4-oxo-4-phenylbutanoic acid (1434254-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; iodine / acetonitrile / 1 h / 0 - 30 °C

2: dipyridinium dichromate / N,N-dimethyl-formamide / 15 h / 30 °C

With dipyridinium dichromate; iodine; sodium hydrogencarbonate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/ejoc.201201128

upstream raw materials:

2-(tert-butyloxycarbonylamino)-3-(2-phenyl-1,3-dithian-2-yl)propan-1-ol

C₂₁H₃₁NO₃S₂

(R)-3-(tert-butyloxycarbonylamino)-4-hydroxy-1-phenylbutan-1-one

C₁₁H₂₀INO₃