2-(tert-butyloxycarbonylamino)-3-(2-phenyl-1,3-dithian-2-yl)propan-1-ol

Base Information

• Chemical Name: 2-(tert-butyloxycarbonylamino)-3-(2-phenyl-1,3-dithian-2-yl)propan-1-ol
• CAS No.: 1434253-91-4
• Molecular Formula: C₁₈H₂₇NO₃S₂
• Molecular Weight: 369.549
• Mol file: 1434253-91-4.mol

Synonyms:2-(tert-butyloxycarbonylamino)-3-(2-phenyl-1,3-dithian-2-yl)propan-1-ol

Chemical Property of 2-(tert-butyloxycarbonylamino)-3-(2-phenyl-1,3-dithian-2-yl)propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butyloxycarbonylamino)-3-(2-phenyl-1,3-dithian-2-yl)propan-1-ol

There total 3 articles about 2-(tert-butyloxycarbonylamino)-3-(2-phenyl-1,3-dithian-2-yl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C21H31NO3S2 (1434253-83-4) → 2-(tert-butyloxycarbonylamino)-3-(2-phenyl-1,3-dithian-2-yl)propan-1-ol (1434253-91-4)

Guidance literature:

With trifluoroacetic acid; In methanol;

DOI:10.1016/j.tetasy.2015.04.016

Reference yield:

2-Phenyl-[1,3]dithiane (5425-44-5) → 2-(tert-butyloxycarbonylamino)-3-(2-phenyl-1,3-dithian-2-yl)propan-1-ol (1434253-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -20 °C

1.2: -20 °C

2.1: trifluoroacetic acid / methanol / 0 °C

With n-butyllithium; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane;

DOI:10.1002/ejoc.201201128

Reference yield:

C11H20INO3 (1434253-82-3) → 2-(tert-butyloxycarbonylamino)-3-(2-phenyl-1,3-dithian-2-yl)propan-1-ol (1434253-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -20 °C

1.2: -20 °C

2.1: trifluoroacetic acid / methanol / 0 °C

With n-butyllithium; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane;

DOI:10.1002/ejoc.201201128

upstream raw materials:

C₂₁H₃₁NO₃S₂

C₁₁H₂₀INO₃

2-Phenyl-[1,3]dithiane

Downstream raw materials:

(R)-3-(tert-butyloxycarbonylamino)-4-hydroxy-1-phenylbutan-1-one

(R)-2-((tert-butoxycarbonyl)amino)-4-oxo-4-phenylbutanoic acid

(1R,3S)-dodecanoic acid (3-hydroxy-1-hydroxymethyl-3-phenylpropyl)amide