(1S,5R)-8-[2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-(7S)-pyridin-2-yl-6,8-diazabicyclo[3.2.1]octane

Base Information

Chemical Name:(1S,5R)-8-[2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-(7S)-pyridin-2-yl-6,8-diazabicyclo[3.2.1]octane
CAS No.:511521-61-2
Molecular Formula:C₂₅H₃₇N₃OSi
Molecular Weight:423.674
Hs Code.:

Synonyms:(1S,5R)-8-[2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-(7S)-pyridin-2-yl-6,8-diazabicyclo[3.2.1]octane

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Chemical Property of (1S,5R)-8-[2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-(7S)-pyridin-2-yl-6,8-diazabicyclo[3.2.1]octane

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Technology Process of (1S,5R)-8-[2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-(7S)-pyridin-2-yl-6,8-diazabicyclo[3.2.1]octane

There total 5 articles about (1S,5R)-8-[2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-(7S)-pyridin-2-yl-6,8-diazabicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 511521-57-6
(1S,5S)-8-[2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-7-pyridin-2-yl-6,8-diazabicyclo[3.2.1]oct-6-ene

: 511521-61-2
(1S,5R)-8-[2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-(7S)-pyridin-2-yl-6,8-diazabicyclo[3.2.1]octane

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 48h;
DOI:10.1021/jo026711s

Reference yield:

: 109-04-6
2-bromo-pyridine

: 511521-61-2
(1S,5R)-8-[2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-(7S)-pyridin-2-yl-6,8-diazabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / hexane; diethyl ether / 0.5 h / -70 °C

1.2: 97 percent / diethyl ether / 5 h / -70 °C

2.1: NaH / tetrahydrofuran / 0 - 20 °C

2.2: 95 percent / tetrahydrofuran / 16 h / 20 °C

3.1: 68 percent / H₂ / Pd/C / methanol / 48 h / 20 °C

With n-butyllithium; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; hexane;
DOI:10.1021/jo026711s

Reference yield:

: 88056-92-2
(-)-2-cyano-6-phenyloxazolopiperidine

: 511521-61-2
(1S,5R)-8-[2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-(7S)-pyridin-2-yl-6,8-diazabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / hexane; diethyl ether / 0.5 h / -70 °C

1.2: 97 percent / diethyl ether / 5 h / -70 °C

2.1: NaH / tetrahydrofuran / 0 - 20 °C

2.2: 95 percent / tetrahydrofuran / 16 h / 20 °C

3.1: 68 percent / H₂ / Pd/C / methanol / 48 h / 20 °C

With n-butyllithium; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; hexane;
DOI:10.1021/jo026711s