(R)-6-((R)-1-Benzyloxymethyl-propyl)-2,2-dimethyl-[1,3]dioxane-4-carbonitrile

Base Information

Chemical Name:(R)-6-((R)-1-Benzyloxymethyl-propyl)-2,2-dimethyl-[1,3]dioxane-4-carbonitrile
CAS No.:724765-05-3
Molecular Formula:C₁₈H₂₅NO₃
Molecular Weight:303.401
Hs Code.:

Synonyms:(R)-6-((R)-1-Benzyloxymethyl-propyl)-2,2-dimethyl-[1,3]dioxane-4-carbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-6-((R)-1-Benzyloxymethyl-propyl)-2,2-dimethyl-[1,3]dioxane-4-carbonitrile

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Technology Process of (R)-6-((R)-1-Benzyloxymethyl-propyl)-2,2-dimethyl-[1,3]dioxane-4-carbonitrile

There total 7 articles about (R)-6-((R)-1-Benzyloxymethyl-propyl)-2,2-dimethyl-[1,3]dioxane-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 77-76-9
2,2-dimethoxy-propane

: 724765-04-2
(4R,5R)-5-Benzyloxymethyl-2,4-dihydroxy-heptanenitrile

: 724765-05-3
(R)-6-((R)-1-Benzyloxymethyl-propyl)-2,2-dimethyl-[1,3]dioxane-4-carbonitrile

Guidance literature:: With pyridinium p-toluenesulfonate; In acetone; for 2h; Heating;
DOI:10.1002/anie.200453697

Reference yield:

: 724765-03-1
(3R,4R)-4-Benzyloxymethyl-hexane-1,3-diol

: 724765-05-3
(R)-6-((R)-1-Benzyloxymethyl-propyl)-2,2-dimethyl-[1,3]dioxane-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: TEMPO; aq. KBr; NaOCl / NaHCO₃ / CH₂Cl₂ / 0.33 h / 0 °C

2.1: 18-crown-6; TMSCN / CH₂Cl₂ / 2 h / 23 °C

2.2: 499 mg / pyridinium p-toluenesulfonate / CH₂Cl₂; methanol / 14 h / 23 °C

3.1: 97 percent / pyridinium p-toluenesulfonate / acetone / 2 h / Heating

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; 18-crown-6 ether; trimethylsilyl cyanide; pyridinium p-toluenesulfonate; potassium bromide; sodium hydrogencarbonate; In dichloromethane; acetone;
DOI:10.1002/anie.200453697

Reference yield:

: 724765-02-0
(2R,3R)-2-ethyl-5-[(4-methoxyphenyl)methoxy]pentane-1,3-diol

: 724765-05-3
(R)-6-((R)-1-Benzyloxymethyl-propyl)-2,2-dimethyl-[1,3]dioxane-4-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 70 percent / NaH / toluene / 2.5 h / -60 - 23 °C

2.1: 98 percent / aq. HCl / ethanol / 29 h / 90 °C

3.1: TEMPO; aq. KBr; NaOCl / NaHCO₃ / CH₂Cl₂ / 0.33 h / 0 °C

4.1: 18-crown-6; TMSCN / CH₂Cl₂ / 2 h / 23 °C

4.2: 499 mg / pyridinium p-toluenesulfonate / CH₂Cl₂; methanol / 14 h / 23 °C

5.1: 97 percent / pyridinium p-toluenesulfonate / acetone / 2 h / Heating

With hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; 18-crown-6 ether; trimethylsilyl cyanide; pyridinium p-toluenesulfonate; sodium hydride; potassium bromide; sodium hydrogencarbonate; In ethanol; dichloromethane; acetone; toluene;
DOI:10.1002/anie.200453697