Technology Process of (7R,11R,15R)-16-tert-butyldimethylsilyloxy-1-tert-butyldiphenylsilyloxy-11-hydroxy-5-phenylsulfonyl-3,7,11,15-tetramethyl-4-hexadecanone
There total 22 articles about (7R,11R,15R)-16-tert-butyldimethylsilyloxy-1-tert-butyldiphenylsilyloxy-11-hydroxy-5-phenylsulfonyl-3,7,11,15-tetramethyl-4-hexadecanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 6 h
2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2.2: 0 - 20 °C
3.1: pyridinium chlorochromate / dichloromethane / 20 °C / Molecular sieve
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
4.2: -78 - -20 °C / Inert atmosphere
5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C
With
1H-imidazole; n-butyllithium; Dess-Martin periodane; 9-bora-bicyclo[3.3.1]nonane; pyridinium chlorochromate;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.09.066
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: ammonia; lithium / -40 °C
2.1: pyridine / 0 °C
3.1: sodium iodide / acetone / 20 °C / Reflux
4.1: N,N-dimethyl-formamide / 6 h
5.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
5.2: -78 - -20 °C / Inert atmosphere
6.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C
With
pyridine; n-butyllithium; ammonia; lithium; Dess-Martin periodane; sodium iodide;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetone;
1.1: Birch reduction;
DOI:10.1016/j.tet.2011.09.066
