3-broMo-4-ethyoxylbenzonitrile

Base Information

• Chemical Name: 3-broMo-4-ethyoxylbenzonitrile
• CAS No.: 136366-42-2
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.073
• Mol file: 136366-42-2.mol

Synonyms:3-bromo-4-ethoxybenzonitrile

Chemical Property of 3-broMo-4-ethyoxylbenzonitrile

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-4-ethoxybenzonitrile 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-broMo-4-ethyoxylbenzonitrile

There total 5 articles about 3-broMo-4-ethyoxylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C10H12BrNO2 (1428637-14-2) → 3-bromo-4-ethoxybenzonitrile (136366-42-2)

Guidance literature:

With [Ru(η⁶-p-cymene)Cl₂]₂; diphenyl acetylene; In isopropyl alcohol; at 100 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1039/c3cc41124a

Reference yield: 93.8%

→ 3-bromo-4-ethoxybenzonitrile (136366-42-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield: 29.0%

2-bromo-1-ethoxy-4-methylbenzene (103260-55-5) → 3-bromo-4-ethoxybenzonitrile (136366-42-2)

Guidance literature:

With sodium azide; copper(ll) sulfate pentahydrate; [bis(acetoxy)iodo]benzene; In acetonitrile; at -40 - 25 ℃; Inert atmosphere;

DOI:10.1002/anie.200903838

upstream raw materials:

ethyl iodide

2-bromo-1-ethoxy-4-methylbenzene

C₁₀H₁₂BrNO₂

3-bromo-4-hydroxybenzonitrile

Refernces

• 1、 -. "2 - (3-cyano-4-alkoxy) phenyl-4-substituted thiazole-5- formic acid class compound, composition and its preparation and use". Paragraph 0104; 0107; 0108. . Retrieved 2016/10/07.
• 2、 Zhou, Wang,Zhang, Liangren,Jiao, Ning. "Direct transformation of methyl arenes to aryl nitriles at room temperature". supporting information; experimental part. p. 7094 - 7097. Retrieved 2009/12/28.