diethyl ((7-bromo-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)phosphonate

Base Information

Chemical Name:diethyl ((7-bromo-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)phosphonate
CAS No.:1610520-73-4
Molecular Formula:C₁₃H₁₇BrNO₄PS
Molecular Weight:394.226
Hs Code.:

Synonyms:diethyl ((7-bromo-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)phosphonate

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Chemical Property of diethyl ((7-bromo-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)phosphonate

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Technology Process of diethyl ((7-bromo-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)phosphonate

There total 1 articles about diethyl ((7-bromo-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28948-60-9
2-bromothieno[3,2-c]pyridin-4(5H)-one

: 1610520-73-4
diethyl ((7-bromo-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)phosphonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - -60 °C / Inert atmosphere

1.2: 1 h / -60 - 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran / 24 h / 20 °C

3.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C

3.2: 20 °C

4.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C / Inert atmosphere

5.1: phosphorus tribromide / 1,4-dioxane / 2 h / 40 °C / Inert atmosphere

6.1: toluene / 120 °C / Inert atmosphere

With sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; phosphorus tribromide; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; toluene;

Reference yield:

: 1610520-73-4
diethyl ((7-bromo-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)phosphonate

: 1610518-48-3
2-((4-(benzylsulphonyl)piperazin-1-yl)methyl)-7-(3,4-dimethoxyphenyl)-5-methylthieno[3,2-c]pyridin-4(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.75 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / water; isopropyl alcohol / 0.5 h / 130 °C / Microwave irradiation

3.1: palladium 10% on activated carbon; ammonium formate / water; ethanol / 2 h / 90 °C / Inert atmosphere

4.1: dmap; pyridine / dichloromethane / 19 h / 20 - 40 °C

4.2: 4 h / 60 °C

With pyridine; dmap; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; palladium 10% on activated carbon; ammonium formate; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 1610520-73-4
diethyl ((7-bromo-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)phosphonate

: 1610518-67-6
7-(3,4-dimethoxyphenyl)-5-methyl-2-((1-(methylsulphonyl)piperidin-4-yl)methyl)thieno[3,2-c]pyridin-4(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.75 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / water; isopropyl alcohol / 0.5 h / 130 °C / Microwave irradiation

3.1: palladium 10% on activated carbon; ammonium formate / water; ethanol / 2 h / 90 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 5 h / Inert atmosphere

5.1: pyridine / dichloromethane / 19 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; palladium 10% on activated carbon; ammonium formate; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water; isopropyl alcohol;