7-(3,4-dimethoxyphenyl)-5-methyl-2-(piperidin-4-ylmethyl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride

Base Information

Chemical Name:7-(3,4-dimethoxyphenyl)-5-methyl-2-(piperidin-4-ylmethyl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride
CAS No.:1610520-80-3
Molecular Formula:C₂₂H₂₆N₂O₃S*ClH
Molecular Weight:434.987
Hs Code.:

Synonyms:7-(3,4-dimethoxyphenyl)-5-methyl-2-(piperidin-4-ylmethyl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride

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Chemical Property of 7-(3,4-dimethoxyphenyl)-5-methyl-2-(piperidin-4-ylmethyl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride

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Technology Process of 7-(3,4-dimethoxyphenyl)-5-methyl-2-(piperidin-4-ylmethyl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride

There total 9 articles about 7-(3,4-dimethoxyphenyl)-5-methyl-2-(piperidin-4-ylmethyl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1610520-79-0
tert-butyl 4-((7-(3,4-dimethoxyphenyl)-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methyl)piperidine-1-carboxylate

: 1610520-80-3
7-(3,4-dimethoxyphenyl)-5-methyl-2-(piperidin-4-ylmethyl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 5h; Inert atmosphere;

Reference yield:

: 28948-60-9
2-bromothieno[3,2-c]pyridin-4(5H)-one

: 1610520-80-3
7-(3,4-dimethoxyphenyl)-5-methyl-2-(piperidin-4-ylmethyl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 - -60 °C / Inert atmosphere

1.2: 1 h / -60 - 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran / 24 h / 20 °C

3.1: caesium carbonate / tetrahydrofuran / 0.33 h / 20 °C

3.2: 20 °C

4.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C / Inert atmosphere

5.1: phosphorus tribromide / 1,4-dioxane / 2 h / 40 °C / Inert atmosphere

6.1: toluene / 120 °C / Inert atmosphere

7.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.75 h / Inert atmosphere

7.2: 20 °C / Inert atmosphere

8.1: potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / water; isopropyl alcohol / 0.5 h / 130 °C / Microwave irradiation

9.1: palladium 10% on activated carbon; ammonium formate / water; ethanol / 2 h / 90 °C / Inert atmosphere

10.1: hydrogenchloride / 1,4-dioxane / 5 h / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; palladium 10% on activated carbon; ammonium formate; phosphorus tribromide; potassium carbonate; caesium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; water; isopropyl alcohol; toluene;

Reference yield:

: 1610520-74-5
tert-butyl 4-((7-bromo-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-2-yl)methylene)piperidine-1-carboxylate

: 1610520-80-3
7-(3,4-dimethoxyphenyl)-5-methyl-2-(piperidin-4-ylmethyl)thieno[3,2-c]pyridin-4(5H)-one hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / water; isopropyl alcohol / 0.5 h / 130 °C / Microwave irradiation

2: palladium 10% on activated carbon; ammonium formate / water; ethanol / 2 h / 90 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 5 h / Inert atmosphere

With hydrogenchloride; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; palladium 10% on activated carbon; ammonium formate; potassium carbonate; In 1,4-dioxane; ethanol; water; isopropyl alcohol;