Ethyl 4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylate

Base Information

Chemical Name:Ethyl 4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylate
CAS No.:135427-10-0
Molecular Formula:C₂₄H₂₄FNO₂
Molecular Weight:377.458
Hs Code.:
DSSTox Substance ID:DTXSID801131501

Synonyms:DTXSID801131501;Ethyl 4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylate;135427-10-0

Suppliers and Price of Ethyl 4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylate

Chemical Property:

XLogP3:6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:377.17910717
Heavy Atom Count:28
Complexity:497

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C(C(=C1C2=CC=C(C=C2)F)C)C3=CC=CC=C3)C(C)C

Technology Process of Ethyl 4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylate

There total 5 articles about Ethyl 4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

concentrated NH₄ OH: concentrated NH₄ OH

NH₄ OAc: NH₄ OAc

: 122252-56-6
β-(4-fluorophenyl)-α-(2-methyl-1-oxopropyl)-δ-oxobenzenepentanoic acid, ethyl ester

: 135427-10-0
4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylic acid ethyl ester

Guidance literature:: Cu(OAc)2; SiO₂; In glacial HOAc; hexane; water; ethyl acetate;

Reference yield: 87.0%

: 135427-07-5
β-(4-fluorophenyl)-α-(2-methyl-1-oxopropyl)-δ-oxobenzenepentanoic acid ethyl ester

: 135427-10-0
4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylic acid ethyl ester

Guidance literature:: With copper diacetate; ammonium acetate; In acetic acid; for 24h; Heating;
DOI:10.1021/jm00113a019

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 135427-10-0
4-(4-fluorophenyl)-5-methyl-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

3: 87 percent / NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

With piperidine; copper diacetate; ammonium acetate; acetic acid; lithium hexamethyldisilazane; In acetic acid; benzene;
DOI:10.1021/jm00113a019